T-448 free base
T-448 free base is a specific, orally active, CNS-penetrant and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. T-448 free base enhances H3K4 methylation in primary cultured rat neurons.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1597426-52-2
- 分子式: C17H20N4OS
- 分子量:328.43
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Seclidemstat (Standard)Reference Standard -
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Seclidemstat mesylate (Standard)Reference Standard
生物活性
製品説明
IC50 & Target
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KDM1/LSD1 |
体外実験
T-448 enhances the levels of H3K4 methylation, increased mRNA expression of neural plasticity-related genes including brain derived neurotrophic factor (Bdnf), and ameliorated learning dysfunction[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Primary cultured rat neurons.
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Concentration:0-10 μM.
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Incubation Time:1 day treatment.
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Result:Increased Ucp2 H3K4me2 and Ucp2 mRNA significantly.
体内実験
T-448 increases H3K4 methylation in the brain without causing hematological side effects even at 100 mg/kg[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NR1-hypo mice[1].
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Dosage:1, 10 mg/kg.
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Administration:Orally, 3 weeks.
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Result:Dose-dependently increased the H3K4me2 levels around Bdnf, Arc, and Fos genes in the mouse hippocampus.
Resulted in partial but statistically significant and dosedependent rescue effects on the rate of correct choices in NR1-hypo mice.
化学情報
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CAS 番号 1597426-52-2
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分子量 328.43
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分子式 C17H20N4OS
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SMILES
O=C(NC1=NN=C(C)S1)C2=CC=CC([C@H]3[C@H](NC4CCC4)C3)=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
T-448 free base 関連分類
HY-122635 関連分類
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