1597426-52-2

T-448 free base Chemical Structure
1597426-52-2

Chemical Structure

T-448 free base

  • CAS No.: 1597426-52-2
  • Formula:C17H20N4OS
  • Molecular Weight:328.43

IUPAC Name: 3-((1S,2R)-2-(cyclobutylamino)cyclopropyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzamide

InChIKey: HQRYNOVKRKLADI-LSDHHAIUSA-N

SMILES: O=C(NC1=NN=C(C)S1)C2=CC=CC([C@H]3[C@H](NC4CCC4)C3)=C2

Biological Activity: T-448 free base is a specific, orally active, CNS-penetrant and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. T-448 free base enhances H3K4 methylation in primary cultured rat neurons[1].

Cat. No. Product Name Purity Description Pricing
HY-122635 		T-448 free base T-448 free base is a specific, orally active, CNS-penetrant and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. T-448 free base enhances H3K4 methylation in primary cultured rat neurons.
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