1597426-53-3
1597426-53-3
Chemical Structure
T-448
- CAS No.: 1597426-53-3
- Formula:C17H20N4OS.1/2C4H4O4
- Molecular Weight:386.50
SMILES: O=C(NC1=NN=C(C)S1)C2=CC=CC([C@H]3[C@H](NC4CCC4)C3)=C2.O=C(O)/C=C/C(O)=O.[1/2]
Biological Activity: T-448 is a specific, orally active, CNS-penetrant and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. T-448 enhances H3K4 methylation in primary cultured rat neurons[1].
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T-448 | 98.42% | T-448 is a specific, orally active, CNS-penetrant and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. T-448 enhances H3K4 methylation in primary cultured rat neurons. | ||||||||||||||||||||
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References
Keywords
