SKF 38393 hydrobromide
Based on 24 publication(s) in Google Scholar
SKF 38393 ((±)-SKF-38393) hydrobromide is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM.
For research use only. We do not sell to patients.
- CAS No.: 20012-10-6
- Formula: C16H18BrNO2
- Molecular Weight:336.22
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) SKF 38393 hydrobromide
More- Nat Commun. 2024 May 1;15(1):3685. [Abstract]
- Neuron. 2026 May 19:S0896-6273(26)00332-6. [Abstract]
- Neuron. 2024 Apr 3;112(7):1150-1164.e6. [Abstract]
- Microbiome. 2020 Aug 20;8(1):120. [Abstract]
- J Clin Invest. 2026 Jan 15;136(5):e196944. [Abstract]
- Adv Sci (Weinh). 2026 Jul;13(37):e19913. [Abstract]
- Adv Sci (Weinh). 2025 Aug 23:e03409. [Abstract]
- J Neuroinflammation. 2026 Apr 23. [Abstract]
- Acta Pharmacol Sin. 2026 Apr 24. [Abstract]
- Acta Pharmacol Sin. 2025 May 6. [Abstract]
- Free Radic Biol Med. 2023 Jun:202:2-16. [Abstract]
- Cell Rep. 2025 Mar 1;44(3):115364. [Abstract]
- EMBO Rep. 2022 Feb 3;23(3):e53191. [Abstract]
- Eur J Pharmacol. 2024 Oct 15:981:176866. [Abstract]
- J Affect Disord. 2024 Jul 1:356:586-596. [Abstract]
- Biomedicines. 2024 May 9;12(5):1046. [Abstract]
- Aquaculture. 2025 Apr 15.
- Insect Biochem Mol Biol. 2025 May:180:104312. [Abstract]
- Neurobiol Aging. 2021 Jun:102:1-16. [Abstract]
- Behav Brain Res. 2022 Mar 26:422:113759. [Abstract]
- Med Sci Monit. 2021 Oct 18;27:e933278. [Abstract]
- bioRxiv. 2026 Jan 6:2026.01.06.697936. [Abstract]
- bioRxiv. 2020 Jun.
- bioRxiv. 2019 Oct.
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All Dopamine Receptor Isoforms
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Biological Activity
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D1 Receptor 110 nM (IC50) |
SKF 38393 hydrobromide induces a similar change in cytomorphology and increases the levels of media cAMP[2].
SKF-38393 hydrochloride (10 μM; 1 hour) induces increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:GC cells
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Concentration:10 μM
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Incubation Time:1 hour
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Result:Induced increased threonine-phosphorylation of DARPP-32 in cultured GC cells.
SKF 38393 hydrobromide attenuates MPTP-induced depletion of dopamine[3].
SKF 38393 hydrobromide enhances the activity of superoxide dismutase and hence mimics the action of Selegiline[3].
SKF 38393 hydrobromide enhances the frequency but not the amplitude of tetrodotoxin-resistant excitatory postsynaptic currents which argues for a presynaptic locus of D1 action[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/c mice (20-25 g)[3]
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Dosage:5 mg/kg, 10 mg/kg
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Administration:Intraperitoneal injection
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Result:Blocked the MPTP-induced depletion of glutathione and attenuated MPTP-induced depletion of dopamine.
Chemical Information
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CAS No. 20012-10-6
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Molecular Weight 336.22
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Formula C16H18BrNO2
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SMILES
OC1=C(O)C=C2C(C3=CC=CC=C3)CNCCC2=C1.[H]Br
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Synonyms
(±)-SKF-38393 hydrobromide
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (24)
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Journal Impact Factor
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Most Recent
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Nat Commun
Large-language models facilitate discovery of the molecular signatures regulating sleep and activity. [Abstract]2024 May 1;15(1):3685. PMID: 38693116 -
Neuron
Hyperexcitable VTA-mPFC dopaminergic circuit disrupts sleep spindle and mediates sleep fragmentation after chronic social defeat stress. [Abstract]2026 May 19:S0896-6273(26)00332-6. PMID: 42161276 -
Neuron
The Calmodulin-interacting peptide Pcp4a regulates feeding state-dependent behavioral choice in zebrafish. [Abstract]2024 Apr 3;112(7):1150-1164.e6. PMID: 38295792 -
Microbiome
The gut microbiota regulates autism-like behavior by mediating vitamin B6 homeostasis in EphB6-deficient mice. [Abstract]2020 Aug 20;8(1):120. PMID: 32819434
SKF 38393 hydrobromide purchased from MedChemExpress. Usage Cited in: Microbiome. 2020 Aug 20;8(1):120. [Abstract]
After the injection of D1R agonist SKF 38393 hydrochloride (0.0625 μg/0.3 μL; 30 min) in mPFC of 8-week-old male KO mice, olfactory habituation/dishabituation test or three-chambered social approach task was conducted with an interval of 1 week.
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J Clin Invest
A midbrain-cortical circuit mediated by a claustrum neuronal ensemble orchestrates drug-paired context memory processing. [Abstract]2026 Jan 15;136(5):e196944. PMID: 41538288
SKF 38393 hydrobromide purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2026 Jan 15;136(5):e196944. [Abstract]
SKF 38393 hydrochloride (1 mg/mL; 5 min). Analysis of CPP behavior of METH-exposed male mice and representative heatmap of time spent in CPP apparatus.
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Adv Sci (Weinh)
Nigra-Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice. [Abstract]2026 Jul;13(37):e19913. PMID: 41944312 -
Adv Sci (Weinh)
Corticosterone Contributes to Context-Triggered Retrieval of Morphine Withdrawal Memories by Acting on Basolateral Amygdala Neurons Projecting to Nucleus Accumbens Core. [Abstract]2025 Aug 23:e03409. PMID: 40847673
SKF 38393 hydrobromide purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 23:e03409. [Abstract]
SKF 38393 hydrochloride (10 μM) significantly increased frequency and amplitude of mEPSCsin the MN + SKF group.
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J Neuroinflammation
Dopamine signaling governs macrophage-mediated acute lung injury through JAML/IL-10-coupled mitochondrial regulation. [Abstract]2026 Apr 23. PMID: 42026623 -
Acta Pharmacol Sin
Dopamine abrogates immunosuppression mediated by PD-L1 of cancer stem cells in a preclinical triple-negative breast cancer model. [Abstract]2026 Apr 24. PMID: 42032133 -
Acta Pharmacol Sin
Dysfunction of subthalamic dopaminergic circuitry contributes to anxiety- and depression-like behaviors in 6-OHDA lesion-induced hemiparkinsonian mice. [Abstract]2025 May 6. PMID: 40329003
SKF 38393 hydrobromide purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2025 May 6. [Abstract]
SKF 38393 hydrochloride (SKF) (1 μM; 300 nL; i.t.) significantly increased the duration in the center area of the open field arena and the open arms of the EPM and shortened immobility time in the TST and FST in C57BL/6J mice subjected to 6-OHDA injection in the MFB.
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Free Radic Biol Med
Dopamine D1 receptor agonist alleviates acute lung injury via modulating inflammatory responses in macrophages and barrier function in airway epithelial cells. [Abstract]2023 Jun:202:2-16. PMID: 36965538 -
Cell Rep
2025 Mar 1;44(3):115364. PMID: 40023842 -
EMBO Rep
ZFP207 sustains pluripotency by coordinating OCT4 stability, alternative splicing and RNA export. [Abstract]2022 Feb 3;23(3):e53191. PMID: 35037361 -
Eur J Pharmacol
The role of heterodimers formed by histamine H3 receptors and dopamine D1 receptors on the methamphetamine-induced conditioned place preference. [Abstract]2024 Oct 15:981:176866. PMID: 39089461 -
J Affect Disord
Pramipexole improves depression-like behavior in diabetes mellitus with depression rats by inhibiting NLRP3 inflammasome-mediated neuroinflammation and preventing impaired neuroplasticity. [Abstract]2024 Jul 1:356:586-596. PMID: 38657764
SKF 38393 hydrobromide purchased from MedChemExpress. Usage Cited in: J Affect Disord. 2024 Jul 1:356:586-596. [Abstract]
SKF 38393 hydrochloride (SKF) (10 mg/kg; i.p.) significantly upregulated D1R proteins and downregulated NLRP3 signaling pathway-related proteins in the hippocampus of DD (diabetes mellitus with depression) rats.
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Biomedicines
Enhancing Osteogenic Potential: Controlled Release of Dopamine D1 Receptor Agonist SKF38393 Compared to Free Administration. [Abstract]2024 May 9;12(5):1046. PMID: 38791008 -
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Insect Biochem Mol Biol
Molecular and pharmacological characterization of the dopamine receptors in the oriental fruit fly, Bactrocera dorsalis. [Abstract]2025 May:180:104312. PMID: 40245998 -
Neurobiol Aging
Dopaminergic modulation of working memory and cognitive flexibility in a zebrafish model of aging-related cognitive decline. [Abstract]2021 Jun:102:1-16. PMID: 33676049 -
Behav Brain Res
Activation of dopamine D2 receptors in the shell of nucleus accumbens triggers conditioned avoidance responses in rats. [Abstract]2022 Mar 26:422:113759. PMID: 35051488 -
Med Sci Monit
Salicylate Induced GABAAR Internalization by Dopamine D1-Like Receptors Involving Protein Kinase C (PKC) in Spiral Ganglion Neurons. [Abstract]2021 Oct 18;27:e933278. PMID: 34657931 -
bioRxiv
Host GPCR-cAMP signaling balances Gαs and Gαi activity to control intracellular Brucella infection. [Abstract]2026 Jan 6:2026.01.06.697936. PMID: 41542404 -
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Purity & Documentation
References
[1]. Altar CA, et al. Picomolar affinity of 125I-SCH 23982 for D1 receptors in brain demonstrated with digital subtraction auto radiography. J Neurosci. 1987 Jan;7(1):213-222. [Content Brief]
[2]. Mayerhofer A, et al. Functional Dopamine-1 Receptors and DARPP-32 Are Expressed in Human Ovary and Granulosa Luteal Cells in Vitro. J Clin Endocrinol Metab. 1999 Jan;84(1):257-64. [Content Brief]
[3]. Muralikrishnan D, et al. SKF-38393, a dopamine receptor agonist, attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. Brain Res. 2001 Feb 23;892(2):241-7. [Content Brief]
[4]. Bouron A, et al. The D1 dopamine receptor agonist SKF-38393 stimulates the release of glutamate in the hippocampus. Neuroscience. 1999;94(4):1063-70. [Content Brief]
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