1. Membrane Transporter/Ion Channel
    Metabolic Enzyme/Protease
  2. Potassium Channel
    Endogenous Metabolite
  3. 20-HETE

20-HETE (Synonyms: 20-hydroxy Arachidonic Acid)

Cat. No.: HY-15598
Handling Instructions

20-HETE(20-hydroxy Arachidonic Acid) is a potent vasoconstrictor produced in vascular smooth muscle (VSM) cells.

For research use only. We do not sell to patients.

20-HETE Chemical Structure

20-HETE Chemical Structure

CAS No. : 79551-86-3

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2 mg USD 168 In-stock
Estimated Time of Arrival: December 31
5 mg USD 278 In-stock
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10 mg USD 426 In-stock
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50 mg USD 1440 In-stock
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100 mg USD 2520 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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20-HETE(20-hydroxy Arachidonic Acid) is a potent vasoconstrictor produced in vascular smooth muscle (VSM) cells. It depolarizes VSM by blocking the open-state probability of Ca2+-activated K+-channels. IC50 Value: Target: 20-Hydroxyeicosatetraenoic acid (20-HETE) is a cytochrome P450-derived arachidonic acid metabolite that has been shown to increase smooth muscle contractions and proliferation, stimulate endothelial dysfunction and activation and promote hypertension. in vitro: Addition of 20-HETE to the bath (1-100 nM), reduced the frequency of opening of the large-conductance Ca(2+)-activated K+ channel recorded using cell-attached patches on VSM [1]. In kidney, 20-HETE induces diuresis by inhibiting Na+-K+-ATPase in proximal tubules and Na+/K+/Cl+ cotransporter in the thick ascending limb of Henle's loop [2]. in vivo: In Cyp4a14(-/-) mice, which display androgen-driven and 20-HETE-dependent hypertension, treatment with20-HETE antagonist abolished remodeling of renal resistance arteries measured as media thickness (24±1 vs. 15±1μm) and M/L (0.29±0.03 vs. 0.17±0.01) [4]. The transgenic mice had overexpressed hepatic CYP4F2, high hepatic 20-HETE and fasting plasma glucose levels but normal insulin level. The GP activity was increased and the cAMP/PKA-PhK-GP pathway was activated in the transgenic mice compared with wild-type mice [5]. Clinical trial: Mechanisms of Response to Diesel Exhaust in Subjects With Asthma. Phase not specified

IC50 & Target

Human Endogenous Metabolite


Molecular Weight









Room temperature in continental US; may vary elsewhere


4°C, protect from light, stored under argon

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under argon)

Solvent & Solubility
In Vitro: 

Ethanol : 6.67 mg/mL (20.81 mM; Need ultrasonic)

DMSO : ≥ 3.2 mg/mL (9.99 mM)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1204 mL 15.6021 mL 31.2042 mL
5 mM 0.6241 mL 3.1204 mL 6.2408 mL
10 mM 0.3120 mL 1.5602 mL 3.1204 mL
*Please refer to the solubility information to select the appropriate solvent.
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