1. Cell Cycle/DNA Damage
  2. Checkpoint Kinase (Chk)

CCT244747 

Cat. No.: HY-18175 Purity: >98.0%
Data Sheet SDS Handling Instructions

CCT244747 is potent, highly selective, orally active, ATP competitive CHK1 inhibitor with IC50 of 29-170nM.

For research use only. We do not sell to patients.
CCT244747 Chemical Structure

CCT244747 Chemical Structure

CAS No. : 1404095-34-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO $135 In-stock
2 mg $90 In-stock
5 mg $150 In-stock
10 mg $240 In-stock
25 mg $450 In-stock
50 mg $750 In-stock
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

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  • References

Description

CCT244747 is potent, highly selective, orally active, ATP competitive CHK1 inhibitor with IC50 of 29-170nM. target: CHK1 IC 50: 29-170nM [1] In vitro: CCT244747 significantly enhances the cytotoxicity of several anticancer drugs and abrogated drug-induced S and G2 arrest in multiple tumor cell lines. producing enhanced DNA damage and apoptosis. [1] CCT244747 abrogated radiation-induced G2 arrest in the p53-deficient HNSCC cell lines, HN4 and HN5, causing cells to enter mitosis with unrepaired DNA damage [2].CCT244747 modulates the DNA damage response pathway in human tumor xenografts and showed antitumor activity in combination with genotoxic chemotherapies and as a single agent. [3]

References
Molecular Weight

408.46

Formula

C₂₀H₂₄N₈O₂

CAS No.

1404095-34-6

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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CCT244747
Cat. No.:
HY-18175
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