1. Alkaloid

Cantharidin 

Cat. No.: HY-N0209 Purity: >98.0%
Handling Instructions

Cantharidin, a natural toxin isolated from beetles in the families Meloidae and Oedemeridae, has been reported to be toxic to some pests, including the diamondback moth.

For research use only. We do not sell to patients.

Cantharidin Chemical Structure

Cantharidin Chemical Structure

CAS No. : 56-25-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
25 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 96 In-stock
Estimated Time of Arrival: December 31
100 mg USD 126 In-stock
Estimated Time of Arrival: December 31
500 mg USD 504 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

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Customer Review

    Cantharidin purchased from MCE. Usage Cited in: Biochem Pharmacol. 2017 Aug 15;138:49-60.

    Dose-dependent effects of Cantharidin on AMPK-related signaling in three HCC cell lines. The phosphorylation of AMPK is markedly upregulated, and so is its downstream effector phospho-ULK1, whereas PP5 expression is not affected after Cantharidin treatment.

    Cantharidin purchased from MCE. Usage Cited in: Biochem Pharmacol. 2017 Aug 15;138:49-60.

    Blockade of AMPK signals by AMPK α2 siRNA or AMPK inhibitor (Dorsomorphin; 2.5 μM, pretreatment 2 hours) treatment counteracts the apoptotic effects of Cantharidin at 2.5 μM. Data are representative of at least two independent experiments. Blocking AMPK signaling by knockdown of AMPK or Dorsomorphin (AMPK kinase inhibitor) treatment markedly reverses the apoptotic effect of Cantharidin, indicating that AMPK activation is required for the anti-HCC activity of Cantharidin.

    Cantharidin purchased from MCE. Usage Cited in: Biochem Pharmacol. 2017 Aug 15;138:49-60.

    PP5 overexpression suppresses AMPK-Thr172 phosphorylation induced by AMPK activators, AICAR and metformin. Hep3B cells are transfected with indicated plasmids and treated with AICAR (2 mM; 3 h) or Metformin (3 mM; 16 h) to simulate AMPK phosphorylation.

    Cantharidin purchased from MCE. Usage Cited in: Lung Cancer. 2017 Oct;112:81-89.

    Dose-and time-dependent effects of Cantharidin on p-AMPK, PARP, and Caspase 9. Cells are treated with Cantharidin at indicated concentrations for 24 hours or 2.5 μM Cantharidin for different time durations. The protein levels are analyzed with indicated antibodies.

    Cantharidin purchased from MCE. Usage Cited in: Oncol Lett. 2018 May;15(5):6527-6532.

    Cantharidin (CTD) enhances A549 cells autophagy. Western blotting of autophagy associated proteins LC3 I , LC3 II, Beclin 1 and p62 are analyzed.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Cantharidin, a natural toxin isolated from beetles in the families Meloidae and Oedemeridae, has been reported to be toxic to some pests, including the diamondback moth. IC50 value: Target: In vitro: A 48 h treatment of human erythrocytes with cantharidin significantly increased the percentage of annexin-V-binding cells (≥10 μg/mL), significantly decreased forward scatter (≥25 μg/mL), significantly increased [Ca2+]i (≥25 μg/mL), but did not significantly modify ceramide abundance or ROS [1]. In vivo:

    Clinical Trial
    Solvent & Solubility
    In Vitro: 

    10 mM in DMSO

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.0968 mL 25.4842 mL 50.9684 mL
    5 mM 1.0194 mL 5.0968 mL 10.1937 mL
    10 mM 0.5097 mL 2.5484 mL 5.0968 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Cantharidin is prepared in vehicle (normal saline)[4].

    References
    Molecular Weight

    196.20

    Formula

    C₁₀H₁₂O₄

    CAS No.

    56-25-7

    SMILES

    O=C1OC([[email protected]]2(C)[[email protected]@](O3)([H])CC[[email protected]@]3([H])[[email protected]@]21C)=O

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
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    Inquiry Information

    Product Name:
    Cantharidin
    Cat. No.:
    HY-N0209
    Quantity:

    Cantharidin

    Cat. No.: HY-N0209