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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
46 Results for "
Deruxtecan
" in MedChemExpress (MCE) Product Catalog:
Products (46)
46 Results for "Deruxtecan" in MCE Product Catalog:
32
Target:
研究分野:
Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing Trastuzumab deruxtecan (HY-138298A) and Patritumab deruxtecan (HY-P99813) .
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9
9 Cited Publications
別名: T-DXd (solution); DS-8201 (solution); DS-8201a (solution)
5
Target:
研究分野:
Disitamab vedotin (RC48) is an antibody-drug conjugate (ADC) comprising a monoclonal antibody against human epidermal growth factor receptor 2 (HER2) conjugated via a cleavable linker to the cytotoxic agent Monomethyl auristatin E (MMAE) (HY-15162), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E). Disitamab vedotin enhances antitumor immunity .
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2 Cited Publications
別名: DS-1062 (solution); Dato-DXd (solution)
2
2 Cited Publications
製品番号: HY-P99843
CAS 番号: 2267989-53-5
Target:
研究分野:
2
研究分野:
Datopotamab deruxtecan (DS-1062) is a TROP2-targeted antibody-drug conjugate (ADC) with human TROP2 Kd of 0.74 nmol/L. Datopotamab deruxtecan consists of the antibody Datopotamab (HY-P99843) and the toxic molecule-linker conjugate Deruxtecan (HY-13631E). Datopotamab deruxtecan binds TROP2, triggers internalization and lysosomal trafficking and releases DXd topoisomerase I inhibitor payload. Datopotamab deruxtecan disrupts DNA function, induces DNA damage, apoptosis, and bystander killing of tumor microenvironment cells. Datopotamab deruxtecan can be used in research related to triple-negative breast cancer, gastric cancer, and non-small cell lung cancer .
1
Target:
研究分野:
Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) consisting of a fully human anti-HER3 IgG1 monoclonal antibody Patritumab (HY-P99275) attached to a topoisomerase I inhibitor payload via a tetrapeptide-based cleavable linker. Patritumab deruxtecan shows anticancer activity .
1
1 Cited Publications
製品番号: HY-164152A
1
1 Cited Publications
製品番号: HY-164152
研究分野:
製品番号: HY-P3371
CAS 番号: 2484870-92-8
別名: DS-7300a; MABX-9001a; I-DXd
研究分野:
研究分野:
Gly-Mal-GGFG-Deruxtecan 2-hydroxypropanamide is the drug-linker conjugate for ADC, containing ADC linker Gly-Mal-GGFG and ADC cytotoxin Deruxtecan 2-hydroxypropanamide .
Target:
研究分野:
Deruxtecan 2-hydroxypropanamide is a highly stable Deruxtecan (HY-13631E) analog that specifically binds to receptors highly expressed in tumor cells .
製品番号: HY-164734
CAS 番号: 2610074-57-0
別名: R-DXd; DS-6000
Target:
研究分野:
Raludotatug Deruxtecan is an antibody-drug conjugate targeting CDH6, with an EC50 of 64.7 ng/mL in humans, 70.4 ng/mL in cynomolgus monkeys, and 228 ng/mL in mice. Raludotatug Deruxtecan specifically binds to CDH6 on the surface of cancer cells, triggers lysosomal internalization, and releases the DXd payload that inhibits TOP1. Raludotatug Deruxtecan induces DNA damage, Chk1 phosphorylation, caspase-3 cleavage, apoptosis, and bystander cell death. Raludotatug Deruxtecan is applicable to research related to serous ovarian cancer and renal cell carcinoma .
製品番号: HY-P990028
CAS 番号: 2610074-56-9
研究分野:
製品番号: HY-45672
CAS 番号: 1599440-20-6
Target:
研究分野:
Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is an ADC Linker that can be used to synthesize Drug-Linker Conjugates for ADC. Especially for the synthesis of Deruxtecan (HY-13631E), a toxic drug-linker conjugate .
製品番号: HY-177442
別名: DS-3939
製品番号: HY-13631EG
CAS 番号: 1599440-13-7
別名: MC-GGFG-DXD (GMP)
製品番号: HY-13631ES4
別名: MC-GGFG-DXD-d5
製品番号: HY-164835
CAS 番号: 2760408-75-9
別名: VcMMAE-(PAB-GGFG-AMAA)Exatecan; SMP-54418
研究分野:
VcMMAE-Deruxtecan (VcMMAE-(PAB-GGFG-AMAA)Exatecan; SMP-54418) is a drug-linker conjugate for ADC, composed of linker-payload molecule conjugate VcMMAE (HY-15575) and linker-payload molecule conjugate Deruxtecan (PAB-GGFG-AMAA)Exatecan) (HY-13631E). VcMMAE-Deruxtecan can be used in the synthesis of ADCs.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
