1. MAPK/ERK Pathway
    Stem Cell/Wnt
  2. ERK
  3. ERK1/2 inhibitor 1

ERK1/2 inhibitor 1 

Cat. No.: HY-112287
Handling Instructions

ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.

For research use only. We do not sell to patients.

ERK1/2 inhibitor 1 Chemical Structure

ERK1/2 inhibitor 1 Chemical Structure

CAS No. : 2095719-90-5

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Description

ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively[1].

IC50 & Target[1]

ERK2

3.0 nM (IC50)

ERK1

 

In Vitro

ERK1/2 inhibitor 1 (Compound 27) shows excellent antiproliferative potency with IC50s of 4.9 and 7.5 nM in A375 and Colo205 cells, respectively[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

550.05

Formula

C₂₉H₃₂ClN₅O₄

CAS No.

2095719-90-5

SMILES

ClC1=CN=C(NC2CCOCC2)N=C1C3=CC=C(CN([[email protected]](C)C(N[[email protected]](CO)C4=CC=CC(C)=C4)=O)C5=O)C5=C3

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
ERK1/2 inhibitor 1
Cat. No.:
HY-112287
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ERK1/2 inhibitor 1

Cat. No.: HY-112287