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Uprosertib

(Synonyms: GSK2141795)
19 Cited Publications
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Based on 19 publication(s) in Google Scholar

Uprosertib (GSK2141795) is a potent and selective pan-Akt inhibitor with IC50 values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively.

For research use only. We do not sell to patients.

  • Purity: 99.93%
  • CAS No.: 1047634-65-0
  • Formula: C18H16Cl2F2N4O2
  • Molecular Weight:429.25
  • Storage:

    -20°C, stored under nitrogen

    * In solvent : -80°C, 1 year; -20°C, 6 months (stored under nitrogen)

  • Uprosertib Chemical Structure
    Uprosertib Chemical Structure
  • Experimental Validation Results for Uprosertib
  • Experimental Validation Results for Uprosertib
  • Experimental Validation Results for Uprosertib
CAS No.: 1047634-65-0
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • Uprosertib Chemical Structure
    Uprosertib Chemical Structure
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  • 1/16

    Uprosertib purchased from MedChemExpress. Usage Cited in: Oncotarget. 2018 Jul 31;9(59):31549-31558. [Abstract]

    Customer Validation
     Western blots of the indicated proteins in the DMS114-P and DMS114-R cells treated with (+) and without (-) the AKT inhibitor, Uprosertib (200 nM) for 6 h (left panel) or 24 h (right panel). In the case of DMS114-P, extracts with (+) and without (-) treatment with PD173074 (1 µM) are also shown.

  • 1/16

    Uprosertib purchased from MedChemExpress. Usage Cited in: Nat Commun. 2017 Sep 4;8(1):410. [Abstract]

    Customer Validation
     Effect of EGFR TKIs and Akt inhibitors on key signal transduction proteins in parental and resistant PC9 cells. Western blot analysis of PC9 and PC9-ER treated for 4 h with Erlotinib (30 µM), GSK2141795 (2.5 µM) or the combination.

  • 1/16

    Uprosertib purchased from MedChemExpress. Usage Cited in: Mol Cancer Ther. 2017 Apr;16(4):614-624. [Abstract]

    Customer Validation
     Western blot analysis is performed with lysates from resistant cell lines treated either with vehicle (DMSO) or GSK2141795 (1 μM) for 24 hours to assess inhibition of Akt (pAKT) and downstream (pGSK3) signaling (three experimental replicates).

  • Uprosertib