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Kinetin (Synonyms: 6-Furfuryladenine; N6-Furfuryladenine)

Cat. No.: HY-N0160 Purity: 99.38%
Handling Instructions

Kinetin (N6-furfuryladenine) belongs to the family of N6-substituted adenine derivatives known as cytokinins, which are plant hormones involved in cell division, differentiation and other physiological processes. Kinetin has anti-aging effects.

For research use only. We do not sell to patients.

Kinetin Chemical Structure

Kinetin Chemical Structure

CAS No. : 525-79-1

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Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
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Estimated Time of Arrival: December 31
Solid
500 mg USD 55 In-stock
Estimated Time of Arrival: December 31
1 g USD 66 In-stock
Estimated Time of Arrival: December 31
5 g USD 119 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Kinetin

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Kinetin (N6-furfuryladenine) belongs to the family of N6-substituted adenine derivatives known as cytokinins, which are plant hormones involved in cell division, differentiation and other physiological processes. Kinetin has anti-aging effects[1].

In Vitro

Kinetin (N6-furfuryladenine) shows to have a direct effect on superoxide dismutase activity in plants; prevent oxidation of unsaturated acids in plant membranes; slow down development and aging in insects, by reducing their fecundity and increasing the specific activity of catalase; and delay the onset of many age-related characteristics that appear in normal human skin fibroblasts undergoing aging in vitro. Kinetin (70-150 μM) markedly suppressed hydroxyl radical formation by about 41% and 76%, respectively[1].
The plant cytokinin kinetin dramatically increases exon 20 inclusion in RNA isolated from cultured familial dysautonomia (FD) cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Kinetin (N6-furfuryladenine) (2-6 mg/kg; injection into the tail vein) effectively prevents ADP-induced acute pulmonary thrombosis in mice[1].
Subjects received 23.5 mg/kg/d for 28 d. An increase in WT IKBKAP mRNA expression in leukocytes was noted after 8 d in six of eight individuals; after 28 d, the mean increase compared with baseline was significant[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ADP-induced acute pulmonary thrombosis 20-24 g mice (ICR strain)[1]
Dosage: 2, 4, 6 mg/kg
Administration: Injection into the tail vein
Result: Reduced mortality to 70%, 40% and 35% at 2, 4, and 6 mg/kg, respectively.
Clinical Trial
Molecular Weight

215.21

Formula

C10H9N5O

CAS No.
SMILES

C12=NC=NC(NCC3=CC=CO3)=C1N=CN2

Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (154.87 mM; Need ultrasonic)

H2O : 1 mg/mL (4.65 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6466 mL 23.2331 mL 46.4662 mL
5 mM 0.9293 mL 4.6466 mL 9.2932 mL
10 mM 0.4647 mL 2.3233 mL 4.6466 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (11.62 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (11.62 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (11.62 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 99.38%

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Kinetin
Cat. No.:
HY-N0160
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