LY2409881
Based on 5 publication(s) in Google Scholar
LY2409881 is a selective IκB kinase β (IKK2) inhibitor with an IC50 of 30 nM.
For research use only. We do not sell to patients.
- CAS No.: 946518-61-2
- Formula: C24H29ClN6OS
- Molecular Weight:485.04
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) LY2409881
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Biological Activity
Description
IC50 & Target
[1]|
IKK2 30 nM (IC50) |
In Vitro
LY2409881 is an IKK2 inhibitor that inhibits TNFα-induced activation of NF-κB. By in vitro kinase assay, LY2409881 potently inhibits IKK2, with an IC50 of 30 nM. In contrast, the IC50 for IKK1 and other common kinases is at least one log higher. The specificity of LY2409881 for NF-κB signaling is further studied in a cell-based assay, by examining the effect of LY2409881 in the TNFα-dependent antiapoptosis function. TNFα is a well-characterized upstream stimulus of NF-κB. In the ovarian cancer cell line SKOV3, LY2409881 demonstrates moderate cytotoxicity, whereas TNFα at 10 ng/mL does not cause any cytotoxicity. In contrast, coadministration of LY2409881 and TNFα results in markedly higher cell killing compared with LY2409881. This is because TNFα-dependent activation of antiapoptotic signals mediated by NF-κB is blocked by LY2409881, while the proapoptotic TNF receptor-associated death domain (TRADD) and FAS-associated death domain (FADD) cascade pathways activated by TNFα are not affected by LY2409881[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 946518-61-2
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Molecular Weight 485.04
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Formula C24H29ClN6OS
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SMILES
O=C(C1=C(C=C(C2=NC(NCCCN3CCN(C)CC3)=NC=C2Cl)S4)C4=CC=C1)NC5CC5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (5)
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Journal Impact Factor
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Most Recent
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Acta Pharmacol Sin
2026 Mar 11. PMID: 41813972 -
Clin Transl Med
Uterus globulin associated protein 1 (UGRP1) binds podoplanin (PDPN) to promote a novel inflammation pathway during Streptococcus pneumoniae infection. [Abstract]2022 Jun;12(6):e850. PMID: 35652821 -
Cell Rep
Polo-like kinase 2 promotes microglial activation via regulation of the HSP90α/IKKβ pathway. [Abstract]2024 Oct 8;43(10):114827. PMID: 39383034 -
Int J Mol Sci
Salicylate Sodium Suppresses Monocyte Chemoattractant Protein-1 Production by Directly Inhibiting Phosphodiesterase 3B in TNF-α-Stimulated Adipocytes. [Abstract]2022 Dec 24;24(1):320. PMID: 36613764 -
iScience
Pan-cancer analysis reveals Rho kinase addiction as a vulnerability of de-differentiated cancer cells. [Abstract]2026 Jun 2;29(6):116031. PMID: 42369662
Solvent & Solubility
In Vitro:
DMSO : ≥ 37 mg/mL (76.28 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0617 mL | 10.3084 mL | 20.6169 mL | 51.5421 mL |
| 5 mM | 0.4123 mL | 2.0617 mL | 4.1234 mL | 10.3084 mL | |
| 10 mM | 0.2062 mL | 1.0308 mL | 2.0617 mL | 5.1542 mL | |
| 15 mM | 0.1374 mL | 0.6872 mL | 1.3745 mL | 3.4361 mL | |
| 20 mM | 0.1031 mL | 0.5154 mL | 1.0308 mL | 2.5771 mL | |
| 25 mM | 0.0825 mL | 0.4123 mL | 0.8247 mL | 2.0617 mL | |
| 30 mM | 0.0687 mL | 0.3436 mL | 0.6872 mL | 1.7181 mL | |
| 40 mM | 0.0515 mL | 0.2577 mL | 0.5154 mL | 1.2886 mL | |
| 50 mM | 0.0412 mL | 0.2062 mL | 0.4123 mL | 1.0308 mL | |
| 60 mM | 0.0344 mL | 0.1718 mL | 0.3436 mL | 0.8590 mL |
LY2409881 Related Classifications
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