1. NF-κB
  2. IKK

LY2409881 

Cat. No.: HY-B0788 Purity: 98.77%
Data Sheet SDS Handling Instructions

LY2409881 is a novel selective inhibitor of IKK2 with IC50 of 30 nM; IC50 for IKK1 and other common kinases is at least one log higher.

For research use only. We do not sell to patients.
LY2409881 Chemical Structure

LY2409881 Chemical Structure

CAS No. : 946518-61-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $121 In-stock
5 mg $110 In-stock
10 mg $180 In-stock
50 mg $650 In-stock
100 mg $910 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of LY2409881:

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  • References

Description

LY2409881 is a novel selective inhibitor of IKK2 with IC50 of 30 nM; IC50 for IKK1 and other common kinases is at least one log higher. IC50 value: 30 nM [1] Target: IKK2 inhibitor in vitro: LY2409881 inhibited constitutively activated NF-κB, and caused concentration- and time-dependent growth inhibition and apoptosis in lymphoma cells. Pretreatment of LY10 with 10 umol/L of LY2409881 prevented the formation of phosphorylated IkB in samples treated with TNFa for 2, 20, and 60 minutes in the presence of abundant IkB protein [1]. in vivo: LY2409881 was safe to mice at three dose levels, 50, 100, and 200 mg/kg, all of which caused significant inhibition of tumor growth. LY2409881 suppressed the activity of the NF-κB subunit p65 in lymphoma cells treated by the HDAC inhibitor romidepsin, underlying a potential mechanism of the marked synergy observed of these two drugs [1].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.0617 mL 10.3084 mL 20.6169 mL
5 mM 0.4123 mL 2.0617 mL 4.1234 mL
10 mM 0.2062 mL 1.0308 mL 2.0617 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

485.04

Formula

C₂₄H₂₉ClN₆OS

CAS No.

946518-61-2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 37 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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LY2409881
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HY-B0788
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