1. GPCR/G Protein
    Immunology/Inflammation
  2. Histamine Receptor

Lodoxamide tromethamine 

Cat. No.: HY-16289 Purity: >98.0%
Handling Instructions

Lodoxamide tromethamine is a medication for the treatment of prophylaxis of mast cell-mediated allergic disease.

For research use only. We do not sell to patients.

Lodoxamide tromethamine Chemical Structure

Lodoxamide tromethamine Chemical Structure

CAS No. : 63610-09-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 483 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
1 mg USD 132 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 396 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
10 mg USD 600 Get quote
50 mg USD 1800 Get quote
100 mg USD 2520 Get quote
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Other Forms of Lodoxamide tromethamine:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Lodoxamide tromethamine is a medication for the treatment of prophylaxis of mast cell-mediated allergic disease.

In Vitro

lodoxamide inhibits compound 48/80-induced histamine release and ionophore-induced 45Ca influx with associated histamine release in purified rat peritoneal mast cells[1].

In Vivo

Lodoxamide has been demonstrated to have cromolyn-like activity when studied in the rat peritoneal mast cell assay (PCA) model3 and in Ascaris antigen-sensitized rhesus monkeys. When given intravenously, orally, or intrabronchially by aerosol, lodoxamide significantly inhibits the increased respiratory frequency and decreased tidal volume induced by antigen challenge in Ascaris-sensitized. anesthetized rhesus monkeys[1]. Addition of lodoxamide tromethamine to Euro-Collins or University of Wisconsin solution results in a marked decrease in lung reperfusion injury as demonstrated by increased oxygenation, decreased microvascular permeability, and increased compliance[2]. Patients treated with lodoxamide tromethamine demonstrate an improvement in daytime breathing difficulty, cough, sputum production, and sleep[3].

Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (36.11 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8054 mL 9.0269 mL 18.0538 mL
5 mM 0.3611 mL 1.8054 mL 3.6108 mL
10 mM 0.1805 mL 0.9027 mL 1.8054 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

553.9

Formula

C₁₉H₂₈ClN₅O₁₂

CAS No.

63610-09-3

SMILES

N#CC1=CC(NC(C(O)=O)=O)=C(Cl)C(NC(C(O)=O)=O)=C1.OCC(CO)(N)CO.OCC(CO)(N)CO

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Lodoxamide tromethamine
Cat. No.:
HY-16289
Quantity:

Lodoxamide tromethamine

Cat. No.: HY-16289