1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. ML365

ML365 

Cat. No.: HY-12345 Purity: 98.91%
Handling Instructions

ML365 is a selective two-pore domain potassium channel KCNK3/TASK1 inhibitor, with an IC50 of 4 nM. ML365 acts as a pharmacological tool that can be used to examine the specific roles of TASK1 channels.

For research use only. We do not sell to patients.

ML365 Chemical Structure

ML365 Chemical Structure

CAS No. : 947914-18-3

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Solution
10 mM * 1 mL in DMSO USD 91 In-stock
Estimated Time of Arrival: December 31
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10 mM * 1 mL
ready for reconstitution
USD 91 In-stock
Estimated Time of Arrival: December 31
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5 mg USD 83 In-stock
Estimated Time of Arrival: December 31
10 mg USD 127 In-stock
Estimated Time of Arrival: December 31
50 mg USD 550 In-stock
Estimated Time of Arrival: December 31
100 mg USD 935 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

    ML365 purchased from MCE. Usage Cited in: J Am Heart Assoc. 2017 Sep 9;6(9). pii: e006465.

    KCNK3-GFP is activated by ONO-RS-082 (ONO) 10 μM (red trace, left) and inhibited by ML365 10 μM (blue trace, right), under voltage-clamp shown in COS7 cells.
    • Biological Activity

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    • Customer Review

    Description

    ML365 is a selective two-pore domain potassium channel KCNK3/TASK1 inhibitor, with an IC50 of 4 nM. ML365 acts as a pharmacological tool that can be used to examine the specific roles of TASK1 channels[1].

    IC50 & Target

    IC50: 4 nM (TASK1/KCNK3), 390 nM (TASK3/KCNK9)[1]

    In Vitro

    ML365 blocks TASK1 channels in both the thallium influx fluorescent assay (IC50 = 4 nM) and an automated electrophysiology assay (IC50 = 16 nM)[1].
    ML365 displays little or no inhibition at 30 μM of more distantly related potassium channels, Kir2.1, potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2), and human ether-a go-go-related gene (hERG)[1].
    ML365 does not exhibit acute toxicity in cell-based assays at concentrations up to 30 μM[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    360.41

    Formula

    C22H20N2O3

    CAS No.
    SMILES

    O=C(C1=C(OC)C=CC=C1)NC2=CC=CC(NC(C3=CC=CC(C)=C3)=O)=C2

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (277.46 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7746 mL 13.8731 mL 27.7462 mL
    5 mM 0.5549 mL 2.7746 mL 5.5492 mL
    10 mM 0.2775 mL 1.3873 mL 2.7746 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 3 mg/mL (8.32 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 3 mg/mL (8.32 mM); Clear solution

    *All of the co-solvents are available by MCE.
    References
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    • Molarity Calculator

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    Product Name:
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    Cat. No.:
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