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Pilocarpine

45 Cited Publications
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Based on 45 publication(s) in Google Scholar

Pilocarpine is an orally active, selective M3 muscarinic acetylcholine receptor agonist. Pilocarpine can induce seizures. Pilocarpine is used in research on conditions such as epilepsy, dry mouth (xerostomia), and elevated intraocular pressure.

For research use only. We do not sell to patients.

  • Purity: 99.89%
  • CAS No.: 92-13-7
  • Formula: C11H16N2O2
  • Molecular Weight:208.26
  • Storage:

    -20°C, protect from light

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

  • Pilocarpine Chemical Structure
    Pilocarpine Chemical Structure
  • Experimental Validation Results for Pilocarpine
  • Experimental Validation Results for Pilocarpine
  • Experimental Validation Results for Pilocarpine
  • Experimental Validation Results for Pilocarpine
  • Experimental Validation Results for Pilocarpine
  • Experimental Validation Results for Pilocarpine
  • Experimental Validation Results for Pilocarpine
  • Experimental Validation Results for Pilocarpine
  • Experimental Validation Results for Pilocarpine
  • Experimental Validation Results for Pilocarpine
  • Experimental Validation Results for Pilocarpine
  • Experimental Validation Results for Pilocarpine
CAS No.: 92-13-7
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  • Pilocarpine Chemical Structure
    Pilocarpine Chemical Structure
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    Pilocarpine purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 May 5;23(1):332. [Abstract]

    Customer Validation
     Seizure scores across different groups of the Pilocarpine (300 mg/kg; i.p.)-induced SE model.

  • 1/16

    Pilocarpine purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 May 5;23(1):332. [Abstract]

    Customer Validation
     Survival rate analysis among groups of the Pilocarpine (300 mg/kg; i.p.)-induced SE model.

  • 1/16

    Pilocarpine purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 May 5;23(1):332. [Abstract]

    Customer Validation
     Immunofluorescence staining of CD86 (pro-inflammatory) and CD206 (anti-inflammatory) expression in microglia within the hippocampus across groups of the Pilocarpine (300 mg/kg; i.p.)-induced SE model.

  • 1/16

    Pilocarpine purchased from MedChemExpress. Usage Cited in: Cells. 2024 Oct 1;13(19):1635. [Abstract]

    Customer Validation
     Mice were intravenously injected with Evans blue or sulfonyl-NHS-biotin tracer, followed by intraperitoneal injection of scopolamine, and finally Pilo (300 mg/kg, ip, single dose) was injected to induce epileptic seizures, with close monitoring. The results indicated increased blood-brain barrier permeability in this Pilo-induced epilepsy model.

  • 1/16

    Pilocarpine purchased from MedChemExpress. Usage Cited in: Cells. 2024 Oct 1;13(19):1635. [Abstract]

    Customer Validation
     Mice were intravenously injected with Evans blue or sulfonyl-NHS-biotin tracer, followed by intraperitoneal injection of scopolamine, and finally Pilo (300 mg/kg, ip, single dose) was injected to induce epileptic seizures, with close monitoring. The results indicated increased blood-brain barrier permeability in this Pilo-induced epilepsy model.

  • 1/16

    Pilocarpine purchased from MedChemExpress. Usage Cited in: Cells. 2024 Oct 1;13(19):1635. [Abstract]

    Customer Validation
     Mice were intravenously injected with Evans blue or sulfonyl-NHS-biotin tracer, followed by intraperitoneal injection of scopolamine, and finally Pilo (300 mg/kg, ip, single dose) was injected to induce epileptic seizures, with close monitoring. The results indicated increased blood-brain barrier permeability in this Pilo-induced epilepsy model.

  • 1/16

    Pilocarpine purchased from MedChemExpress. Usage Cited in: Cell Rep. 2023 Apr 30;42(5):112456. [Abstract]

    Customer Validation
     Latency before the first seizure of PTZ and Pilocarpine ((300 mg/kg; i.p.)-induced seizure tests in RACK1 fl/fl or RACK1 cKO mice.

  • 1/16

    Pilocarpine purchased from MedChemExpress. Usage Cited in: Immunity. 2022 Aug 9;55(8):1466-1482.e9. [Abstract]

    Customer Validation
     The effects of tamoxifen treatment and microglial PDGFB ablation on pilocarpine (100 mg/kg, ip, once every 20 minutes)-induced epilepsy were investigated by implanting telemetry probes into PDGFBNull-MG mice and analyzing their heart rate (HR) and heart rate variability (HRV) before and 3 or 5 weeks after tamoxifen treatment.

  • 1/16

    Pilocarpine purchased from MedChemExpress. Usage Cited in: Cell Mol Neurobiol. 2022 Apr;42(3):777-790. [Abstract]

    Customer Validation
     Pilocarpine (325 mg/kg, ip, single dose)-induced status epilepticus (SE) reduced the level of ALOXE3 protein in the hippocampus of mice, but did not reduce it in the temporal lobe cortex.

  • 1/16

    Pilocarpine purchased from MedChemExpress. Usage Cited in: Cell Mol Neurobiol. 2022 Apr;42(3):777-790. [Abstract]

    Customer Validation
     Pilocarpine (325 mg/kg, ip, single dose)-induced status epilepticus (SE) increases AA levels in the hippocampus of mice.

  • 1/16

    Pilocarpine purchased from MedChemExpress. Usage Cited in: Prog Neurobiol. 2022 Oct:217:102335. [Abstract]

    Customer Validation
     The percentages of Foxp3+ Tregs among CD4+ T cells significantly increased in the hippocampal parenchyma of Pilocarpine(280-300 mg/kg; i.p.)-induced SE mice compared with those in the control group.

  • 1/16

    Pilocarpine purchased from MedChemExpress. Usage Cited in: Prog Neurobiol. 2022 Oct:217:102335. [Abstract]

    Customer Validation
     GFAP immunostaining in the CA1, CA3, and DG regions of the hippocampi of vehicle-treated control mice, PC61-treated control mice, vehicle-treated Pilocarpine (280-300 mg/kg; i.p.) mice, and PC61-treated Pilocarpine mice.

  • Pilocarpine