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R162 

Cat. No.: HY-103096 Purity: 98.92%
Handling Instructions

R162 is a potent inhibitor of glutamate dehydrogenase 1 (GDH1/GLUD1), with anti-cancer properties.

For research use only. We do not sell to patients.

R162 Chemical Structure

R162 Chemical Structure

CAS No. : 64302-87-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 106 In-stock
Estimated Time of Arrival: December 31
5 mg USD 96 In-stock
Estimated Time of Arrival: December 31
10 mg USD 168 In-stock
Estimated Time of Arrival: December 31
25 mg USD 372 In-stock
Estimated Time of Arrival: December 31
50 mg USD 660 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1140 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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  • Purity & Documentation

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  • Customer Review

Description

R162 is a potent inhibitor of glutamate dehydrogenase 1 (GDH1/GLUD1), with anti-cancer properties.

In Vitro

Inhibition of GDH1 activity by R162 treatment results in decreased intracellular fumarate levels, attenuated GPx activity, increased ROS levels, and reduced cell proliferation in H1299 and MDA-MB231 cells, which can be significantly rescued by methyl-α-KG treatment as well as by antioxidant NAC. R162 inhibits cell proliferation and tumor growth potential of human cancer cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

R162 (30 mg/kg/day, i.p.) does not result in a significant histopathological change between the vehicle-treated and R162-treated groups, nor alters complete blood counts, or hematopoietic properties in xenograft tumor mouse models. R162 (20 mg/kg/day) results in significantly decreased tumor growth and masses in mice compared with control mice and effectively inhibits GDH1 activity in resected tumors from xenograft nude mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

264.28

Formula

C₁₇H₁₂O₃

CAS No.

64302-87-0

SMILES

O=C1C2=C(C=CC=C2)C(C3=CC=C(CC=C)C(O)=C13)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : 25 mg/mL (94.60 mM; Need ultrasonic)

DMSO : 5.2 mg/mL (19.68 mM; Need ultrasonic)

Ethanol : 2 mg/mL (7.57 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (ultrasonic) (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7839 mL 18.9193 mL 37.8387 mL
5 mM 0.7568 mL 3.7839 mL 7.5677 mL
10 mM 0.3784 mL 1.8919 mL 3.7839 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMF    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (9.46 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMF    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.46 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 1 mg/mL (3.78 mM); Suspended solution; Need ultrasonic

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1 mg/mL (3.78 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.92%

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Keywords:

R162R 162R-162OthersInhibitorinhibitorinhibit

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Product Name:
R162
Cat. No.:
HY-103096
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