Others

L-Kynurenine-5-F (Compound 2h) is the 5-F derivative of L-Kynurenine (HY-104026).

2-(5,8-Tetradecadienyl)cyclobutanone (HMDB 37519) is a non-functional small molecule that can be extracted from herbal decoctions.

Nucleoside-analog-3 (compound 59) is a S-cEt guanosine intermediate.

2-(3-(Azidomethyl)-2-formyl-6-methylphenoxy)acetic acid (Compound C1-4) is an azide reagent. 2-(3-(Azidomethyl)-2-formyl-6-methylphenoxy)acetic acid can be used in studies of protein fixed-point azidation.

p-DNSB is a bridged compound. p-DNSB shows fluorescence properties (wavelengths in Diethylether: 416 nm (absorption); 574 nm (emission)).

p-DCSB, a Stilbene derivative, is a bridged model compound.

5-MeO-NBpBrT (Compound 2f) (5MT-NB4B) is a NBOMe derivative and 5MT-based N-(bromobenzyl) isomer.

DBNBS is a radical spin trapper. DBNBS rapidly reacts with the Cys-34 residue in BSA to generate hydroxylamine. DBNBS spin traps the protein-centered radicals generated by porphyrin photooxidation of BSA.

SCPI-3 is a potent and competitive mosquito sterol carrier protein-2 (SCP-2) inhibitor (AeSCP-2 IC₅₀ = 0.159 µM; AeSCP-x IC₅₀ = 0.285 µM). SCPI-3 exhibits physiological effects on cholesterol metabolism in cultured insect cells (IC₅₀ of 3.09 µM in Aag-2 cells). SCPI-3 shows insecticidal activity against Aedes aegypti with a LD₅₀ of 12.3 µM.

Tyrosinase-IN-47 (compound 6a) is a potent competitive tyrosinase inhibitor with an IC₅₀ of 1.43 µM and a K_i of 0.1142 μM. Tyrosinase-IN-47 also shows inhibition activity in α-Glucosidase (IC₅₀ = 36.26 μM) and acetylcholinesterase (IC₅₀ = 8.26 μM). Tyrosinase-IN-47 exhibits in vitro antioxidant activity, with good scavenging ability for DPPH (IC₅₀ = 4.75 μM) and ABTS (IC₅₀ = 0.04 μM). Tyrosinase-IN-47 displays anti-browning effect on freshly cut potatoes. Tyrosinase-IN-47 can be used for pharmaceutical research.

PP48 is a compound that interacts with MOB4, with a pTE₅₀ value of 5.4. PP48 interacts with MOB4 (Cys134).

Ac-N-m-(CF3)2-Ph-C-Py (Compound F31) is an electrophilic fragment. Ac-N-m-(CF₃)₂-(phenyl)-C-(pyridyl) can be used in proteomics research.

MRT-31619 formate is a molecular gel degrader (MGD) targeting CRBN. MRT-31619 formate drives the self-dimerization of the E3 ligase by mimicking the degradation subunit, and promotes its rapid, effective and selective degradation through the ubiquitin-proteasome system.

Acaricidal agent-2 (compound 12aa) is a potent acaricidal agent that exhibits activity in T. cinnabarinus. Acaricidal agent-2 exhibits good ovicidal (LC₅₀ = 0.14 mg/L) and larvicidal activities (LC₅₀ = 0.09 mg/L). Acaricidal agent-2 shows low acute toxicity in Zebrafish. Acaricidal agent-2 can be used for pest management.

PPO-IN-24 (compound P12) is a lipophilic protoporphyrinogen oxidase IX (PPO) inhibitor. PPO-IN-24 can be used as a herbicide for weed control.

(4R,5S)-Nutlin carboxylic acid-NHC2-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (4R,5S)-Nutlin carboxylic acid based MDM2 ligand and a linker used in PROTAC technology. (4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3 can be connected to the ligand for protein by a linker to form PROTAC EZH2 Degrader-30 (HY-181359).

MC-GGFG-3-Methylenecyclobutyl (compound L-7B) is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

(S,R,S,R)-AHPC-Me-CO-C7-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S,R)-AHPC-Me based VHL ligand and a linker used in PROTAC technology. (S,R,S,R)-AHPC-Me-CO-C7-N3 can be connected to the ligand for protein by a linker to form PROTAC EZH2 Degrader-28 (HY-181355).

(4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (4R,5S)-Nutlin carboxylic acid based MDM2 ligand and a linker used in PROTAC technology. (4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3 can be connected to the ligand for protein by a linker to form PROTAC EZH2 Degrader-29 (HY-181357).

Herbicide safener-5 is a herbicide (Herbicide) safener. Herbicide safener-5 promotes plant growth recovery, enhances the activities of detoxifying enzymes (ALS, GST, CYP450, POD), and reduces SOD activity. Herbicide safener-5 is applicable to herbicide-related research.