Others

Sucrose dilaurate acts as an emulsifier, dispersant and stabilizer. Sucrose dilaurate reduces the release of HMGB1 from UVB-irradiated keratinocytes. Sucrose dilaurate inhibits melanogenesis and decreases bilirubin levels. Sucrose dilaurate induces autophagy in human epidermal keratinocytes, thereby reducing carboxymethyl lysine (CML) levels. Sucrose dilaurate reduces the secretion of insulin-like growth factor-binding protein 3 (IGFBP3) and nerve growth factor (NGF) by senescent keratinocytes. Sucrose dilaurate is investigated as an emulsifier, dispersant or stabilizer in the cosmetics, food and pharmaceutical industries.

Cy5 MMTr CPG 1000 is a type of fluorescently labeled solid-phase carrier used for the automated synthesis of solid-phase oligonucleotides. During the synthesis process, the Cy5 fluorescent dye can be directly covalently attached to the 3′-end of the oligonucleotide without the need for subsequent liquid-phase labeling. Cy5 MMTr CPG 1000 can be used for the synthesis of 3′-Cy5 labeled oligonucleotides.

Dichloro-all-trans-retinone is a selective retinaldehyde dehydrogenase (RALDH) inhibitor, with an IC₅₀ of 434.7 nM and a K_i of 194.4 nM against chicken RALDH1; an IC₅₀ of 55 nM and a K_i of 5.1 nM against chicken RALDH2; an IC₅₀ of 191.32 nM and a K_i of 64.35 nM against human RALDH2; and an IC₅₀ of 161.27 nM and a K_i of 6.74 nM against chicken RALDH3. Dichloro-all-trans-retinone inhibits the synthesis of all-trans retinoic acid (ATRA). Dichloro-all-trans-retinone is applicable to research related to form-deprivation-induced myopia.

7-Methylguanosine 5-disphosphoimidazolide disodium (7-Me-3'-OMe-GDP imidazole) is a guanosine diphosphate imidazolide and starting material for synthesis of alkyne-containing C-phosphonate and phosphoester clickable mononucleotide building blocks for triazole-modified mRNA cap analogues.

DCAF1 binder 3 is a DCAF1 binder and an E3 ligase ligand. DCAF1 binder 3 can be used to synthesize PROTAC SAMHD1 Degrader-1 (HY-182970).

E3 Ligase Ligand-linker Conjugate 229 is a conjugate of an E3 ligase ligand and a linker, which can be used for the synthesis of PROTAC SAMHD1 Degrader-1 (HY-182970).

Tenovin-3-CO-C9-NH2 is a conjugate of a target protein ligand and a linker, which can be used for the synthesis of PROTAC EV-A71 Degrader-1 (HY-182971).

Mal-PEG4-NPV-PABC-DMEDA is a linker that can be used for the synthesis of ADC molecules.

N3-Methylcytidine phosphoramidite [5′-O-DMT2′-O-TBDMS-m3 CAc] is a phosphoramidite monomer. Phosphoramidites can be used in the synthesis of oligonucleotides.

2′-O-Hexyl-adenosine is a nucleoside derivative that can be used for the synthesis of RNA.

N6-(3-Azidopropanoyl)-N2-(tert-butoxycarbonyl)-L-lysine is an L-lysine (HY-N0469) derivative and an azide molecule used for click chemistry conjugation.

1-(3-Azidopropyl)-1H-pyrrole-2,5-dione is a maleimide derivative with a 3-azidopropyl substituent, used to introduce an azide functional group to bovine serum albumin (BSA). 1-(3-Azidopropyl)-1H-pyrrole-2,5-dione reacts with the free, solvent-accessible thiol group of BSA to produce azide-functionalized BSA, which is used in click chemistry to form a TLL-BSA hetero-dimer.

2-Phenyl-1-octen-7-yn-1-one is an alkyne-functionalized enone with site-selective reactivity toward the N-terminal α-amino group of peptides and proteins. 2-Phenyl-1-octen-7-yn-1-one can undergo click chemistry with azides via its alkyne moiety to enable further protein functionalization. 2-Phenyl-1-octen-7-yn-1-one modifies unprotected peptide libraries as well as proteins including insulin, lysozyme, RNaseA and BCArg.

Serotonin O-phosphate is a metabolite of Tryptamine (HY-B2132).

P2X3 antagonist 40 is a P2X3 antagonist with a human P2X3 receptor pIC₅₀ < 4.52. P2X3 antagonist 40 can be used for research on ATP-mediated proinflammatory fingerprint, including overactive bladder, pain, and chronic cough.

SMARCA2/4-ligand-7 is a SMARCA2/4 ligand, which can be used for the synthesis of PROTACs, such as PROTAC SMARCA2/4 degrader-41 (HY-153425).

E3 Ligase Ligand-linker Conjugate 232 is an E3 ligase ligand-linker conjugate that can be used to synthesize PROTACs, such as PROTAC SMARCA2/4 degrader-41 (HY-153425).

Morpholino G(PhAc) subunit is a nucleoside analog that can be used to synthesize phosphorodiamidate morpholino oligonucleotides (PMO).

(2S)-2-Amino-5-(2-amino-5-hydro-5-methyl-4-imi-dazolon-1-yl)pentanoic acid is an amino acid derivative.

CaMKII-IN-4 is a pyrimidine-based ATP-competitive CaMKIIδ inhibitor with an enzymatic IC₅₀ of >20 μM.