2089135-65-7
Chemical Structure
Dichloro-all-trans-retinone
- CAS No.: 2089135-65-7
- Formula:C21H28Cl2O
- Molecular Weight:367.35
IUPAC Name: (3E,5E,7E,9E)-1,1-dichloro-4,8-dimethyl-10-(2,6,6-trimethylcyclohex-1-en-1-yl)deca-3,5,7,9-tetraen-2-one
InChIKey: NWWAQIKCANAFJE-YCNIQYBTSA-N
SMILES: C(=C/C(=C/C=C/C(=C/C(C(Cl)Cl)=O)/C)/C)\C=1C(C)(C)CCCC1C
Biological Activity: Dichloro-all-trans-retinone is a selective retinaldehyde dehydrogenase (RALDH) inhibitor, with an IC50 of 434.7 nM and a Ki of 194.4 nM against chicken RALDH1; an IC50 of 55 nM and a Ki of 5.1 nM against chicken RALDH2; an IC50 of 191.32 nM and a Ki of 64.35 nM against human RALDH2; and an IC50 of 161.27 nM and a Ki of 6.74 nM against chicken RALDH3. Dichloro-all-trans-retinone inhibits the synthesis of all-trans retinoic acid (ATRA). Dichloro-all-trans-retinone is applicable to research related to form-deprivation-induced myopia[1].
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Dichloro-all-trans-retinone | Dichloro-all-trans-retinone is a selective retinaldehyde dehydrogenase (RALDH) inhibitor, with an IC50 of 434.7 nM and a Ki of 194.4 nM against chicken RALDH1; an IC50 of 55 nM and a Ki of 5.1 nM against chicken RALDH2; an IC50 of 191.32 nM and a Ki of 64.35 nM against human RALDH2; and an IC50 of 161.27 nM and a Ki of 6.74 nM against chicken RALDH3. Dichloro-all-trans-retinone inhibits the synthesis of all-trans retinoic acid (ATRA). Dichloro-all-trans-retinone is applicable to research related to form-deprivation-induced myopia. | |||||||||||||||||||||
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Keywords
