Others

DM175 is a partial agonist of FXR. DM175 binds to the ligand-binding domain of FXR and induces the outward movement of Trp454.

Endosidin7 is a specific inhibitor for plant callose deposition during cytokinesis. Endosidin7 inhibits cytokinesis-specific callose deposition at the cell plate, disrupts cell plate maturation, and alters localization of cell plate-associated proteins during late cell plate development. Endosidin7 slows root growth and induces formation of cell wall stubs in Arabidopsis thaliana seedlings.

(-)-AGN 192403 ((-)-BRD4780) hydrochloride is the enantiomer of AGN 192403 hydrochloride (HY-101374A). AGN 192403 hydrochloride is a potent and selective imidazoline-1 receptor antagonist.

DABMA is a TMEM175 channel activator with a human EC₅₀ of 17.9 μM. DABMA directly increases TMEM175 channel current via interaction with intracellular, transmembrane, or endosomal lumen-associated domains, and does not alter TMEM175 mRNA or protein levels. DABMA delays endolysosomal substrate degradation, modulates endolysosomal trafficking, increases acidic organelle accumulation, induces cholesterol accumulation and altered late endosome morphology. DABMA can be used for the research of coronavirus disease, Clostridium difficile infection, Pseudomonas aeruginosa infection, rabies, and influenza virus infection.

Trantheline bromide is a quaternary ammonium compound. Trantheline bromide represents its intrinsic lipophilicity independent of Galvani potential difference and counter-ion effects. Trantheline bromide is used as a model compound to study the lipophilicity of quaternary ammonium ions via cyclic voltammetry.

U-11634 is an orally active dopamine β-hydroxylase noncompetitive inhibitor, with rat LD₅₀ values of 1197 mg/kg (subcutaneous) and 524 mg/kg (oral). U-11634 blocks conversion of dopamine to norepinephrine and reduces norepinephrine levels in brain. U-11634 decreases food intake and spontaneous motor activity via dietary inclusion. U-11634 induces thyroid toxicity and inhibits pregnancy. U-11634 inhibits deciduomata formation in intact and steroid-treated rats, with no reversal by progesterone or oestradiol. U-11634 can be used for pregnancy.

Aminobutane bisphosphonate is a Trypanosoma cruzi farnesyl pyrophosphate synthase (FPPS) inhibitor with an IC₅₀ of 30.77 μM against Trypanosoma cruzi. Aminobutane bisphosphonate inhibits proliferation of intracellular amastigote Trypanosoma cruzi and lacks activity against non-infective epimastigote forms. Aminobutane bisphosphonate reduces osteoclastic bone resorption, osteoid surface extent, and osteoclast number per mm of bone surface. Aminobutane bisphosphonate can be used for the research of american trypanosomiasis (chagas' disease) and immobilization-related bone loss.

NPS-467 is a calcium-sensing receptor (CaR) activator and stereospecific agent with only its R-enantiomer active. NPS-467 increases the sensitivity of the CaR to activation by extracellular calcium. NPS-467 stimulates stanniocalcin (STC) secretion in trout and induces inhibition of gill calcium transport in trout. NPS-467 has no effect on serum calcitonin levels in trout.

BI 1702135 is a drug intermediate that can be used to synthesize SMARCA2 PROTAC degrader BI 1810284.

Lipid Mixture Standard (69 Mix), DCM:Methanol (1:1) is a mixed standard of isotope internal standards.

XAX-162 is a highly selective sphingosine 1-phosphate receptor 2 (S1PR2) agonist with a human EC₅₀ of 0.55 μM. XAX-162 does not activate other S1P receptors. XAX-162 exhibits noncompetitive inhibition of activity by S1PR2 antagonist JTE-013 (HY-100675).

Tyrphostin AG-808 is a protein tyrosine kinase inhibitor that does not reduce neointimal formation. Perivascular implantation of Tyrphostin AG-808 causes medial damage in rats.

GSH linker-2 is an ADC linker that can be used to synthesize GNE-987 GSH linker-2 (HY-138634).

Sucrose dilaurate acts as an emulsifier, dispersant and stabilizer. Sucrose dilaurate reduces the release of HMGB1 from UVB-irradiated keratinocytes. Sucrose dilaurate inhibits melanogenesis and decreases bilirubin levels. Sucrose dilaurate induces autophagy in human epidermal keratinocytes, thereby reducing carboxymethyl lysine (CML) levels. Sucrose dilaurate reduces the secretion of insulin-like growth factor-binding protein 3 (IGFBP3) and nerve growth factor (NGF) by senescent keratinocytes. Sucrose dilaurate is investigated as an emulsifier, dispersant or stabilizer in the cosmetics, food and pharmaceutical industries.

Cy5 MMTr CPG 1000 is a type of fluorescently labeled solid-phase carrier used for the automated synthesis of solid-phase oligonucleotides. During the synthesis process, the Cy5 fluorescent dye can be directly covalently attached to the 3′-end of the oligonucleotide without the need for subsequent liquid-phase labeling. Cy5 MMTr CPG 1000 can be used for the synthesis of 3′-Cy5 labeled oligonucleotides.

Dichloro-all-trans-retinone is a selective retinaldehyde dehydrogenase (RALDH) inhibitor, with an IC₅₀ of 434.7 nM and a K_i of 194.4 nM against chicken RALDH1; an IC₅₀ of 55 nM and a K_i of 5.1 nM against chicken RALDH2; an IC₅₀ of 191.32 nM and a K_i of 64.35 nM against human RALDH2; and an IC₅₀ of 161.27 nM and a K_i of 6.74 nM against chicken RALDH3. Dichloro-all-trans-retinone inhibits the synthesis of all-trans retinoic acid (ATRA). Dichloro-all-trans-retinone is applicable to research related to form-deprivation-induced myopia.

7-Methylguanosine 5-disphosphoimidazolide disodium (7-Me-3'-OMe-GDP imidazole) is a guanosine diphosphate imidazolide and starting material for synthesis of alkyne-containing C-phosphonate and phosphoester clickable mononucleotide building blocks for triazole-modified mRNA cap analogues.

DCAF1 binder 3 is a DCAF1 binder and an E3 ligase ligand. DCAF1 binder 3 can be used to synthesize PROTAC SAMHD1 Degrader-1 (HY-182970).

E3 Ligase Ligand-linker Conjugate 229 is a conjugate of an E3 ligase ligand and a linker, which can be used for the synthesis of PROTAC SAMHD1 Degrader-1 (HY-182970).

Tenovin-3-CO-C9-NH2 is a conjugate of a target protein ligand and a linker, which can be used for the synthesis of PROTAC EV-A71 Degrader-1 (HY-182971).