893603-33-3
Chemical Structure
DABMA
- CAS No.: 893603-33-3
- Formula:C20H28BrNO
- Molecular Weight:378.35
InChIKey: BMSKZYQEVKGOFK-UHFFFAOYSA-N
SMILES: BrC1=CC=C(C(CNC23CC4CC(C2)(CC(C4)(C3)C)C)=C1)OC
Biological Activity: DABMA is a TMEM175 channel activator with a human EC50 of 17.9 μM. DABMA directly increases TMEM175 channel current via interaction with intracellular, transmembrane, or endosomal lumen-associated domains, and does not alter TMEM175 mRNA or protein levels. DABMA delays endolysosomal substrate degradation, modulates endolysosomal trafficking, increases acidic organelle accumulation, induces cholesterol accumulation and altered late endosome morphology. DABMA can be used for the research of coronavirus disease, Clostridium difficile infection, Pseudomonas aeruginosa infection, rabies, and influenza virus infection[1][2][3].
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DABMA | DABMA is a TMEM175 channel activator with a human EC50 of 17.9 μM. DABMA directly increases TMEM175 channel current via interaction with intracellular, transmembrane, or endosomal lumen-associated domains, and does not alter TMEM175 mRNA or protein levels. DABMA delays endolysosomal substrate degradation, modulates endolysosomal trafficking, increases acidic organelle accumulation, induces cholesterol accumulation and altered late endosome morphology. DABMA can be used for the research of coronavirus disease, Clostridium difficile infection, Pseudomonas aeruginosa infection, rabies, and influenza virus infection. | |||||||||||||||||||||
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- [1]. Wu Y, et al. Endolysosomal channel TMEM175 mediates antitoxin activity of DABMA. FEBS J. 2024;291(18):4142-4154. [Content Brief]
- [2]. Wu Y, et al. DABMA: A Derivative of ABMA with Improved Broad-Spectrum Inhibitory Activity of Toxins and Viruses. ACS Med Chem Lett. 2019;10(8):1140-1147. Published 2019 Jul 2. [Content Brief]
- [3]. Liu H, et al. Antiviral Effects of ABMA and DABMA against Influenza Virus In Vitro and In Vivo via Regulating the Endolysosomal Pathway and Autophagy. Int J Mol Sci. 2022;23(7):3940. Published 2022 Apr 1. [Content Brief]
Keywords
