XAX-162

Cat. No.: HY-182618: Data Sheet Handling Instructions
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XAX-162 is a highly selective sphingosine 1-phosphate receptor 2 (S1PR2) agonist with a human EC₅₀ of 0.55 μM. XAX-162 does not activate other S1P receptors. XAX-162 exhibits noncompetitive inhibition of activity by S1PR2 antagonist JTE-013 (HY-100675).

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XAX-162 Chemical Structure

CAS No. : 883053-48-3

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LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

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Description

IC₅₀ & Target

S1PR2

0.55 μM (EC₅₀)

In Vitro

XAX-162 (0.55 μM) activates S1PR2 in S1PR2 CRE-bla CHO cells with an EC₅₀ of 0.55 μM, reaching a maximum activity 130% of that induced by 1 μM S1P^[1].
XAX-162-mediated receptor activation is inhibited by JTE-013 (HY-100675) in a noncompetitive manner, with reduced response magnitude and right-shifted dose-response curves as JTE-013 concentration increases in S1PR2 CRE-bla CHO cells^[1].
XAX-162 is highly selective for S1PR2, showing no agonist activity in cell-based assays for S1PR1, S1PR3, S1PR4, or S1PR5^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

349.49

Formula

C₁₆H₁₅NO₂S₃

CAS No.

883053-48-3

SMILES

CC(C=C1)=CC=C1SC2=CC=C(C3SCCS3)C=C2[N+]([O-])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Satsu H, et al. A sphingosine 1-phosphate receptor 2 selective allosteric agonist. Bioorg Med Chem. 2013;21(17):5373-5382. [Content Brief]

XAX-162 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XAX-162883053-48-3XAX162XAX 162LPL ReceptorLysophospholipid ReceptorS1P receptorsS1PR5S1PS1PR4sphingosine 1-phosphate receptor 2JTE-013S1PR2 CRE-bla CHO cellsS1PR1S1PR2S1PR3Inhibitorinhibitorinhibit

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