1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. TP-10

TP-10 

Cat. No.: HY-14550 Purity: 98.54%
Handling Instructions

TP-10 is a PDE10A inhibitor with IC50 of 0.8 nM.

For research use only. We do not sell to patients.

TP-10 Chemical Structure

TP-10 Chemical Structure

CAS No. : 898563-00-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

TP-10 is a PDE10A inhibitor with IC50 of 0.8 nM. IC50 value: 0.8 nM [1] Target: PDE10A TP-10 has extremely potent PDE10A inhibitory activity and high selectivity against other PDEs, and be active in the mouse behavioral model for positive symptoms. TP-10 demonstrats good in vitro and in vivo activity, the intrinsic clearance (CLint) of these compounds in mouse liver microsomes (MLM) was extremely high in assay (CLint>1000 mL/min/kg). [1]

Molecular Weight

460.45

Formula

C₂₆H₁₉F₃N₄O

CAS No.

898563-00-3

SMILES

FC(F)(F)CN1C=C(C2=CC=NC=C2)C(C(C=C3)=CC=C3OCC4=NC5=CC=CC=C5C=C4)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (217.18 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1718 mL 10.8589 mL 21.7179 mL
5 mM 0.4344 mL 2.1718 mL 4.3436 mL
10 mM 0.2172 mL 1.0859 mL 2.1718 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.75 mg/mL (5.97 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.75 mg/mL (5.97 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.54%

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Keywords:

TP-10TP10TP 10Phosphodiesterase (PDE)Inhibitorinhibitorinhibit

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Product Name:
TP-10
Cat. No.:
HY-14550
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