2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. TP-10

TP-10 

Cat. No.: HY-14550 Purity: 99.33%
COA Handling Instructions

TP-10 is a selective PDE10A inhibitor with an IC50 value of 0.8 nM. TP-10 shows an antioxidant activity with IC50s of 31.72 and 16.04 μg/ml for DPPH and CUPRAC, respectively. TP-10 can be used for the research of neuropathy.

For research use only. We do not sell to patients.

TP-10 Chemical Structure

TP-10 Chemical Structure

CAS No. : 898563-00-3

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 462 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 462 In-stock
Solid
5 mg USD 420 In-stock
10 mg USD 600 In-stock
50 mg USD 1800 In-stock
100 mg USD 2520 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

TP-10 is a selective PDE10A inhibitor with an IC50 value of 0.8 nM. TP-10 shows an antioxidant activity with IC50s of 31.72 and 16.04 μg/ml for DPPH and CUPRAC, respectively. TP-10 can be used for the research of neuropathy[1][2][3].

IC50 & Target

IC50: 0.8 nM (PDE10A), 31.72 μg/mL (DPPH), 16.04 μg/mL (CUPRAC)[1][3]
In Vitro

TP-10 (10 μg /mL; 24 h) affects total reactive oxygen species in human brain-derived cells (U-87 MG)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: U-87 MG cells
Concentration: 10 μg/ml
Incubation Time: 24 hours
Result: Decreased the total number of ROS-positive cells and showed no toxic effects to U-87 MG cells.
In Vivo

TP-10 (0.1-10 mg/kg; i.h. once) shows an effect on cyclic nucleotides[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CD rats[2]
Dosage: 0.1, 0.32, 1.0, 3.2 and 10 mg/kg
Administration: Subcutaneous injection; 0.1-10 mg/kg once
Result: Dose- and time-dependently increased the levels of both cGMP and cAMP in striatal of mice. Increased pCREB-LI level first and returned to basal levels after injected for 3 hours at a dose of 3.2 mg/kg.
Molecular Weight

460.45

Appearance

Solid

Formula

C26H19F3N4O
CAS No.
SMILES

FC(F)(F)CN1C=C(C2=CC=NC=C2)C(C(C=C3)=CC=C3OCC4=NC5=CC=CC=C5C=C4)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (217.18 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1718 mL 10.8589 mL 21.7179 mL
5 mM 0.4344 mL 2.1718 mL 4.3436 mL
10 mM 0.2172 mL 1.0859 mL 2.1718 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (5.43 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.43 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.38 mg/mL (5.17 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.33%

COA (248 KB) LCMS (98 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

TP-10898563-00-3TP10TP 10Phosphodiesterase (PDE)U-87 MGcGMPcAMPreactive oxygenpCREB-LIschizophreniadisorderInhibitorinhibitorinhibit

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