1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. CDK
  4. CDC Isoform
  5. CDC Inhibitor

CDC Inhibitor

CDC Inhibitors (17):

Cat. No. Product Name Effect Purity
  • HY-100888
    Simurosertib
    Inhibitor 99.07%
    Simurosertib (TAK-931) is an orally active, selective and ATP-competitive cell division cycle 7 (CDC7) kinase inhibitor, with an IC50 of <0.3 nM.
  • HY-112842
    MBQ-167
    Inhibitor 99.67%
    MBQ-167 is a dual Rac/Cdc42 inhibitor, with IC50s of 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively.
  • HY-15260A
    XL413 hydrochloride
    Inhibitor 99.82%
    XL413 (BMS-863233) hydrochloride is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC50 of 3.4 nM, and also shows potent effect with IC50s of 215, 42 nM on CK2, PIM1, respectively, and an EC50 of 118 nM on pMCM.
  • HY-133028
    CKI-7 free base
    Inhibitor 99.34%
    CKI-7 free base is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM.
  • HY-100023
    LY3177833
    Inhibitor 99.76%
    LY3177833 (Example 4) is an orally active CDC7 and pMCM2 inhibitor with IC50 values of 3.3 nM and 290 nM, respectively.
  • HY-100023A
    LY3177833 monhydrate
    Inhibitor 99.76%
    LY3177833 (Example 4) monhydrate is an orally active CDC7 and pMCM2 inhibitor with IC50 values of 3.3 nM and 290 nM, respectively.
  • HY-P3893
    PSTAIR
    Inhibitor
    PSTAIR is a monoclonal antibody that recognizes the PSTAIR sequence in Cdc28, PSTAIR can be used as loading control.
  • HY-143430A
    (S)-LY3177833 hydrate
    Inhibitor
    (S)-LY3177833 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor.
  • HY-15260
    XL413
    Inhibitor
    XL413 is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC50 of 3.4 nM, and also shows potent effect with IC50s of 215, 42 nM on CK2, PIM1, respectively, and an EC50 of 118 nM on pMCM.
  • HY-143430
    (S)-LY3177833
    Inhibitor
    (S)-LY3177833 ((S)-Example 2) is an orally active CDC7 kinase inhibitor.
  • HY-W011109
    CKI-7
    Inhibitor
    CKI-7 is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM.
  • HY-143429
    Cdc7-IN-15
    Inhibitor
    Cdc7-IN-15 (Example 108) is a cdc7 kinase inhibitor.
  • HY-143389
    Cdc7-IN-14
    Inhibitor
    Cdc7-IN-14 (compound 82) is a potent CDC7 inhibitor with an IC50 of <1 nM.
  • HY-143387
    Cdc7-IN-13
    Inhibitor
    Cdc7-IN-13 (compound 84) is a potent CDC7 inhibitor with an IC50 of <1 nM.
  • HY-143432
    Cdc7-IN-18
    Inhibitor
    Cdc7-IN-18 (compound 1-2) is a potent CDC7 inhibitor with an IC50 of 1.29 nM for Cdc7/DBF4 enzyme.
  • HY-143385
    Cdc7-IN-12
    Inhibitor
    Cdc7-IN-12 (compound 1) is a potent CDC7 inhibitor with an IC50 of <1 nM.
  • HY-143433
    Cdc7-IN-19
    Inhibitor
    Cdc7-IN-19 (compound 1-1) is a potent CDC7 inhibitor with an IC50 of 1.49 nM.