Drug Intermediate
Drug Iintermediate
Drug intermediates are used as raw materials for the production of bulk drugs, or they can refer to a material produced during synthesis of an API that must undergo further molecular change or processing before it becomes an API. Drug intermediates are hygienically formulated using high grade raw materials and they are used in the pharmaceutical and cosmetic industry[1][2].
References:
- [1]. Ma HC, et al. Homochiral Covalent Organic Framework for Catalytic Asymmetric Synthesis of a Drug Intermediate. J Am Chem Soc. 2020 Jul 22;142(29):12574-12578. [Content Brief]
- [2]. Ramachary D B, et al. Development of pharmaceutical drugs, drug intermediates and ingredients by using direct organo‐click reactions[J]. 2008.
All Product Categories
-
Drug Intermediate Related Products (4608)
Related Products (4608)
-
N2-Isobutyryl-2'-O-methylguanosine
0 ImagesN2-Isobutyryl-2'-O-methylguanosine is a nucleic acid synthesis intermediate (e.g., used in antisense oligonucleotides, mRNA modification), for example, it is a key monomer for the synthesis of 2'-O-methyl oligoribonucleotides. N2-Isobutyryl-2'-O-methylguanosine enables the final product to form stable double strands with complementary RNA and is not easily degraded by nucleases. N2-Isobutyryl-2'-O-methylguanosine is mainly used in molecular biology research, and can be used to prepare RNA hybridization probes or participate in related biochemical research such as pre-mRNA splicing mechanisms.
-
Orthocaine
0 ImagesOrthocaine is a local analgesic and local anesthetic. Orthocaine can be used for research on superficial painful injuries and various types of pain.
-
DMNB
0 ImagesSynonyms: 6-NitroveratraldehydeDMNB (6-Nitroveratraldehyde) is a photolabile proton donor that releases acidic substances when excited at a wavelength of 405 nM. DMNB can be used for the synthesis of no-carrier-added 6-[18F]fluoro-L-DOPA (6-FDOPA). DMNB is also applicable to the preparation of o-nitroaryl-bis (5-methylfur-2-yl) methanes and the synthesis of alpha-asarone (HY-N0700). DMNB is an enzyme involved in the non-homologous end joining (NHEJ) pathway responsible for DNA double-strand break (DSB) repair. DMNB can be used in PET studies of the dopaminergic system.
-
5-Bromo-6-chloronicotinic acid
0 ImagesCat. No.: HY-W002863CAS No.: 29241-62-15-Bromo-6-chloronicotinic acid is a halogenated nicotinic acid and synthetic starting material that can be used in studies related to organic synthesis.
-
Vanillin acetate
0 ImagesVanillin acetate is a phenol ester that can be synthesized from vanillin by treatment with acetic anhydride.
-
Deiodoamiodarone
0 ImagesCat. No.: HY-114928CAS No.: 23551-25-9Synonyms: L 3937; Dideiodo AmiodaroneDeiodoamiodarone (L 3937; Dideiodo Amiodarone) is an intermediate of amiodarone. Amiodarone is a potent calmodulin antagonist.
-
Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate
0 ImagesEthyl 4-chloro-2-(methylthio) pyrimidine-5-carboxylate is a pharmaceutical intermediate. Ethyl 4-chloro-2-(methylthio) pyrimidine-5-carboxylate can be used to synthesize inhibitors of various kinases (e.g., Cdk4, PDGF, FGF, EGF). Ethyl 4-chloro-2-(methylthio) pyrimidine-5-carboxylate is applicable to research related to cancer and fungal infections.
-
Glyoxal (40% w/w in water)
0 ImagesGlyoxal (40% w/w in water) is an α-oxoaldehyde that inhibits Aldose Reductase, Glutathione Reductase, and NADPH synthase. Glyoxal (40% w/w in water) exhibits cytotoxicity, triggers oxidative stress, induces ROS accumulation, lipid peroxidation, mitochondrial membrane potential collapse, DNA damage, apoptosis, and massive production of advanced glycation end products (AGEs). Glyoxal (40% w/w in water) depletes glutathione and activates MAPK phosphorylation. It has lower toxicity as a fixative than paraformaldehyde (PFA) and serves as a precursor for the synthesis of oxalates and dietary carcinogens. Glyoxal (40% w/w in water) is suitable for research related to calcium oxalate kidney stones, diabetes, atherosclerosis, cardiovascular diseases, retinopathy, and cataracts.
-
(2-Methoxypyrimidin-5-yl)boronic acid
0 Images(2-Methoxypyrimidin-5-yl)boronic acid is a drug intermediate that can serve as a key reactant in the Suzuki-Miyaura coupling reaction, and is used for the synthesis of isoquinoline ketone derivatives with anti-tumor activity.
-
L-Ribulose
0 ImagesCat. No.: HY-121305ACAS No.: 2042-27-5L-Ribulose is an L-form pentulose. L-Ribulose serves as a key precursor for the synthesis of L-ribose and L-nucleoside analogs.
-
Cycloheptane-1,3-dione
0 ImagesCycloheptane-1,3-dione (Compound 1A) is an intermediate. Cycloheptane-1,3-dione can be used to synthesize Compound 1-1. Compound 1-1 has anticancer activity against colon cancer.
-
2,3,4,6-Tetra-O-benzyl-D-glucopyranose
0 ImagesSynonyms: 2,3,4,6-Tetrakis-O-(phenylmethyl)-D-glucopyranose2,3,4,6-Tetra-O-benzyl-D-glucopyranose is a glucose derivative that serves as an important intermediate in the synthesis of complex glycoconjugates, oligosaccharides, and glycosylated drug molecules.
-
1,3-Oxazolidine-2-thione
0 Images1,3-Oxazolidine-2-thione, a free oxazolidinethione, increases thyroid size and severely depresses hepatic trimethylamine oxidase activity in the brown-egg layers.
-
2-Bromoisonicotinic acid
0 Images2-Bromoisonicotinic acid is a (hetero)aryl bromide building block and DNA-conjugated headpiece for photochemical C-H heteroarylation in DNA-encoded library synthesis. 2-Bromoisonicotinic acid generates a nucleophilic pyridyl radical intermediate. 2-Bromoisonicotinic acid, when conjugated to DNA, leaves electrophilic handles intact for subsequent library diversification.
-
4,4'-Dihydroxybenzophenone
0 Images4,4'-Dihydroxybenzophenone is a type of phenolic ultraviolet absorber and a drug intermediate for synthesis of various anticancer active compounds (such as Sivifene (HY-14801)). 4,4'-Dihydroxybenzophenone binds to the active site of trypsin with binding constants (KA = 7.59 x 105 L/moL) and leads to abnormal structure of trypsin, suggesting that long-term intake may affect the digestive function of the human body. 4,4’-dihydroxybenzophenone has a relatively low toxicity to Chlorella vulgaris and a moderate toxicity to Daphnia magna.
-
4-Nitropyrazole
0 Images4-Nitropyrazole is a five-membered nitrogen-containing heterocyclic compound that can be used as a drug intermediate. 4-Nitropyrazole can be synthesized into antibiotics/antifungal/antiviral agents containing pyrazole rings. 4-Nitropyrazole is synthesized through C-H activation reactions to produce LRRK2 inhibitors, which are used in the research of Parkinson's disease.
