Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate
Based on 1 Customer Validation
Ethyl 4-chloro-2-(methylthio) pyrimidine-5-carboxylate is a pharmaceutical intermediate. Ethyl 4-chloro-2-(methylthio) pyrimidine-5-carboxylate can be used to synthesize inhibitors of various kinases (e.g., Cdk4, PDGF, FGF, EGF). Ethyl 4-chloro-2-(methylthio) pyrimidine-5-carboxylate is applicable to research related to cancer and fungal infections.
For research use only. We do not sell to patients.
- Purity : 99.85%
- CAS No.: 5909-24-0
- Formula: C8H9ClN2O2S
- Molecular Weight:232.69
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Storage:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Ethyl 4-chloro-2-(methylthio) pyrimidine-5-carboxylate (8 mmol; refluxed for 2 h) reacts with 3-methylpyridinamine in refluxing dioxane to yield ethyl 2-(methylthio)-4-((pyridin-3-ylmethyl) amino) pyrimidine-5-carboxylate with a yield of 91%[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 5909-24-0
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Appearance Solid
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Molecular Weight 232.69
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Formula C8H9ClN2O2S
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Color White to off-white
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SMILES
O=C(OCC)C1=CN=C(SC)N=C1Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (429.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Klutchko SR, et al. 2-Substituted aminopyrido[2,3-d]pyrimidin-7(8H)-ones. structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity. J Med Chem. 1998 Aug 13;41(17):3276-92. [Content Brief]
[2]. Barvian M, et al. Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases. J Med Chem. 2000 Nov 30;43(24):4606-16. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.2976 mL | 21.4878 mL | 42.9756 mL | 107.4391 mL |
| 5 mM | 0.8595 mL | 4.2976 mL | 8.5951 mL | 21.4878 mL | |
| 10 mM | 0.4298 mL | 2.1488 mL | 4.2976 mL | 10.7439 mL | |
| 15 mM | 0.2865 mL | 1.4325 mL | 2.8650 mL | 7.1626 mL | |
| 20 mM | 0.2149 mL | 1.0744 mL | 2.1488 mL | 5.3720 mL | |
| 25 mM | 0.1719 mL | 0.8595 mL | 1.7190 mL | 4.2976 mL | |
| 30 mM | 0.1433 mL | 0.7163 mL | 1.4325 mL | 3.5813 mL | |
| 40 mM | 0.1074 mL | 0.5372 mL | 1.0744 mL | 2.6860 mL | |
| 50 mM | 0.0860 mL | 0.4298 mL | 0.8595 mL | 2.1488 mL | |
| 60 mM | 0.0716 mL | 0.3581 mL | 0.7163 mL | 1.7907 mL | |
| 80 mM | 0.0537 mL | 0.2686 mL | 0.5372 mL | 1.3430 mL | |
| 100 mM | 0.0430 mL | 0.2149 mL | 0.4298 mL | 1.0744 mL |
Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate Related Classifications
HY-76558 Related Classifications
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