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Cat. No.: HY-W002863

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5-Bromo-6-chloronicotinic acid

Name: 5-Bromo-6-chloronicotinic acid
Brand: MedChemExpress
SKU: HY-W002863
Price: 25.00 USD
Availability: InStock
Rating: 5 (1 reviews)

1 Cited Publications

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5-Bromo-6-chloronicotinic acid is a halogenated nicotinic acid and synthetic starting material that can be used in studies related to organic synthesis.

For research use only. We do not sell to patients.

Purity: 97.34%
CAS No.: 29241-62-1
Formula: C₆H₃BrClNO₂
Molecular Weight:236.45

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

5-Bromo-6-chloronicotinic acid Chemical Structure

CAS No.: 29241-62-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

HY-32837

5-Bromo-2-(hydroxymethyl)pyridine

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Chemical Information
Publications (1)
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Biological Activity

Description

5-Bromo-6-chloronicotinic acid is a halogenated nicotinic acid and synthetic starting material that can be used in studies related to organic synthesis^[1]^[2]^[3].

In Vitro

5-Bromo-6-chloronicotinic acid (compound 35) undergoes carboxylic acid activation and nucleophilic substitution with 4-(chlorodifluoromethoxy) aniline (36) to form amide 37 under specific temperature and solvent conditions^[1].
5-Bromo-6-chloronicotinic acid serves as a starting material for the synthesis of PROTAC molecules GMB-805 (HY-180968) and P19As (HY-180981). These two molecules degrade BCR-ABL in K562 cells, with DC₅₀ values of 30 nM and 200 nM, respectively^[2].
5-Bromo-6-chloronicotinic acid is prepared by oxidation of 3-bromo-2-chloro-5-methylpyridine with potassium dichromate; in addition, this compound can be converted into an acyl chloride intermediate via thionyl chloride, which is used for the synthesis of methylpiperidin-4-ylphenylnicotinamide antitumor candidate molecules^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 29241-62-1
Appearance Solid
Molecular Weight 236.45
Formula C₆H₃BrClNO₂
Color Off-white to light yellow
SMILES

BrC(C=C(C(O)=O)C=N1)=C1Cl
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Benedetto Tiz D, et al. New Halogen-Containing Drugs Approved by FDA in 2021: An Overview on Their Syntheses and Pharmaceutical Use. Molecules (Basel, Switzerland). 2022 Mar 02;27(5):1643.

[2]. Kossakowski K, et al. FDA-approved kinase inhibitors in PROTAC design, development and synthesis. Journal of enzyme inhibition and medicinal chemistry. 2025 Dec;40(1):2542357. [Content Brief]

[3]. Mulik B M, et al. Synthesis, Biological Evaluation, Molecular Docking and ADME Profiling of Methylpiperidin‑4‑ylphenyl‑nicotinamide Derivatives. ChemistrySelect, 2024, 9(14).

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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5-Bromo-6-chloronicotinic acid

1 Cited Publications

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5-Bromo-6-chloronicotinic acid

5-Bromo-2-(hydroxymethyl)pyridine

Publications Citing Use of MedChemExpress (MCE) 5-Bromo-6-chloronicotinic acid

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5-Bromo-6-chloronicotinic acid Related Classifications

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