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P19As

P19As is a BCR-ABL PROTAC degrader based on Asciminib (HY-104010), with a DC50 value of approximately 200 nM for the wild-type BCR-ABL protein. P19As can degrade the T315I mutant and exhibits potent anti-proliferative activity in BaF3-BCR-ABL (T315I) cells. P19As can be used for the study of chronic myeloid leukemia and acute lymphoblastic leukemia.
(Pink: Bcr-Abl ligand (HY-180982); Blue: Cereblon ligand (HY-14658); Black: linker (HY-180978)).

For research use only. We do not sell to patients.

  • CAS No.: 2635386-55-7
  • Formula: C47H51ClF2N12O10
  • Molecular Weight:1017.43
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • P19As Chemical Structure
    P19As Chemical Structure
CAS No.: 2635386-55-7
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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All PROTACs Isoforms

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All Bcr-Abl Isoforms

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100 mg

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  • P19As Chemical Structure
    P19As Chemical Structure
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  • P19As