2075-46-9
2075-46-9
Chemical Structure
4-Nitropyrazole
- CAS No.: 2075-46-9
- Formula:C3H3N3O2
- Molecular Weight:113.08
IUPAC Name: 4-nitro-1H-pyrazole
InChIKey: XORHNJQEWQGXCN-UHFFFAOYSA-N
SMILES: O=[N+](C1=CNN=C1)[O-]
Biological Activity: 4-Nitropyrazole is a five-membered nitrogen-containing heterocyclic compound that can be used as a drug intermediate. 4-Nitropyrazole can be synthesized into antibiotics/antifungal/antiviral agents containing pyrazole rings. 4-Nitropyrazole is synthesized through C-H activation reactions to produce LRRK2 inhibitors, which are used in the research of Parkinson's disease[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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4-Nitropyrazole | 99.99% | 4-Nitropyrazole is a five-membered nitrogen-containing heterocyclic compound that can be used as a drug intermediate. 4-Nitropyrazole can be synthesized into antibiotics/antifungal/antiviral agents containing pyrazole rings. 4-Nitropyrazole is synthesized through C-H activation reactions to produce LRRK2 inhibitors, which are used in the research of Parkinson's disease. | ||||||||||||||||||||
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4-Hydroxymethylpyrazole (Standard) | ≥98% | 4-Hydroxymethylpyrazole (Standard) is the analytical standard of 4-Hydroxymethylpyrazole (HY-33914). This product is intended for research and analytical applications. 4-Hydroxymethylpyrazole is the major phase I oxidative metabolite of 4-Methylpyrazole (HY-B0876) in rats and can be further oxidized to form 4-Carboxypyrazole (HY-W002065). 4-Hydroxymethylpyrazole acts as a substrate and competitive inhibitor of alcohol dehydrogenase (ADH). 4-Hydroxymethylpyrazole can be used in metabolism-related research. | ||||||||||||||||||||
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7-Nitroindazole | 99.09% | 7-Nitroindazole is a selective and BBB-penetrable inhibitor of nitric oxide synthase (NOS) (IC50 = 0.47 μM in mouse cerebellum). 7-Nitroindazole does not affect blood pressure or endothelium-dependent relaxation while inhibiting nNOS in experimental animals. 7-Nitroindazole has anti-injurious and neuroprotective properties, and can be studied in research for neurological diseases such as Parkinson’s disease. | ||||||||||||||||||||
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4-Bromopyrazole | 99.79% | 4-Bromopyrazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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4-Nitroimidazole | 99.9% | 4-Nitroimidazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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Fomepizole | 99.78% | Fomepizole (4-Methylpyrazole) is a potent cytochrome P450 (CYP2E1) inhibitor. Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole has the potential for an antidote for ethylene glycol or methanol poisoning. | ||||||||||||||||||||
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Fomepizole hydrochloride | 99.85% | Fomepizole (4-Methylpyrazole) hydrochloride is a potent and orally active cytochrome P450 (CYP2E1) inhibitor. Fomepizole hydrochloride is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole hydrochloride blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole hydrochloride has the potential for an antidote for ethylene glycol or methanol poisoning. | ||||||||||||||||||||
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4-Iodopyrazole | 99.64% | 4-Iodopyrazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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Azomycin (Standard) | Azomycin (Standard) is the analytical standard of Azomycin. This product is intended for research and analytical applications. Azomycin (2-Nitroimidazole) is an antibiotic which can be active against aerobic Gram-positive and Gram-negative bacteria. | |||||||||||||||||||||
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4-Carboxypyrazole | 99.49% | 4-Carboxypyrazole is a pyrazole metabolite and a human liver alcohol dehydrogenase ligand. It is a metabolite of 4-methylpyrazole in mice and rats and does not inhibit the enzyme when methanol is used as a substrate. 4-Carboxypyrazole can be used in studies related to alcohol dehydrogenase metabolism. | ||||||||||||||||||||
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3-Nitropyrazole | 99.98% | 3-Nitropyrazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research. 3-Nitropyrazole is also a nitrogen-containing heterocyclic compound, which can be used in the synthesis of other active compounds. | ||||||||||||||||||||
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References
- [1]. Manfredini S,et al. Synthesis and antiviral/antitumor activity of some substituted pyrazole and pyrazolo[4,3-d]-1,2,3-triazin-4-one nucleosides. J Med Chem. 1992 Mar 6;35(5):917-24. [Content Brief]
- [2]. Barron B, et al. A Concise Enantioselective Synthesis of Fluorinated Pyrazolo-Piperidine GSK3901383A Enabled by an Organocatalytic Aza-Michael Addition. Org Lett. 2024 Mar 1;26(8):1533-1538. [Content Brief]
- [3]. Hrelia P, et al. Synthesis, metabolism and structure-mutagenicity relationships of novel 4-nitro-(imidazoles and pyrazoles) in Salmonella typhimurium. Mutat Res. 1998 Feb 2;397(2):293-301. [Content Brief]
