Isotope-Labeled Compounds
Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time.
MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.
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Isotope-Labeled Compounds Verwandte Produkte (11046)
Verwandte Produkte (11046)
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Lixisenatide (Leu-13C6,15N) TFA
0 ImagesArt. -Nr.: HY-P0119SLixisenatide (Leu-13C6,15N) TFA is the 13C- and 15N-labeled Lixisenatide (HY-P0119). Lixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist. Lixisenatide inhibits the inflammatory response through down regulation of pro-inflammatory cytokines, and suppresses of the Akt-MEK1/2 signaling pathway. Lixisenatide can inhibit oxidative stress, mitochondrial dysfunction and apoptosis. Lixisenatide can be used for the researches of inflammation, metabolic disease, neurological disease and cardiovascular disease, such as rheumatoid arthritis, diabetes, Alzheimer's disease and atherosclerosis.
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(S)-10-Hydroxycamptothecin-d5
0 ImagesArt. -Nr.: HY-N0095SCAS. Nr.: 1330277-66-1Synonyms: 10-HCPT-d5; 10-Hydroxycamptothecin-d5(S)-10-Hydroxycamptothecin-d5 (10-HCPT-d5) is the deuterium labeled (S)-10-Hydroxycamptothecin. (S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis-inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, colon cancer and leukaemia research.
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2-((2,6-Dimethylphenyl)(2-(methoxy-d3)ethyl)amino)-2-oxoacetic acid
0 ImagesArt. -Nr.: HY-W714702S2-((2,6-Dimethylphenyl)(2-(methoxy-d3)ethyl)amino)-2-oxoacetic acid is deuterium labeled 2-((2,6-Dimethylphenyl)(2-methoxyethyl)amino)-2-oxoacetic acid.
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Tiagabine-d4
0 ImagesArt. -Nr.: HY-B0696S1Synonyms: NO050328-d4; NO328-d4; TGB-d4Tiagabine-d4 (NO050328-d4) is deuterium labeled Tiagabine. Tiagabine (NO050328; NO328; TGB) is an orally active, highly selective, and reversible GAT-1 inhibitor and anticonvulsant that crosses the blood-brain barrier. By blocking the reuptake of GABA in neurons and glial cells, tiagabine increases extracellular GABA levels to enhance inhibitory signal transduction, thereby exerting multiple activities such as anticonvulsant, neuroprotective, and antioxidant effects. Tiagabine exhibits linear pharmacokinetic properties. Although it is metabolized by CYP3A and has a high protein binding rate, it carries a low risk of cognitive impairment. Tiagabine is widely used in research on related diseases including epilepsy (including refractory partial seizures), alcohol withdrawal symptoms, and Huntington's disease.
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Mebeverine acid-d3
0 ImagesArt. -Nr.: HY-12769S2Synonyms: Mebeverine metabolite Mebeverine acid-d3Mebeverine acid-d3 (Mebeverine metabolite Mebeverine acid-d3) is the deuterium labeled Mebeverine Acid (HY-12769). Mebeverine acid is a secondary metabolite of the intestinal antispasmodic agent Mebeverine (HY-A0078). Mebeverine acid is generated by the hydrolysis of Mebeverine in the body and is considered a key circulating metabolite. Mebeverine acid is an important marker for oral Mebeverine.
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(Rac)-Rivastigmine-d6
0 ImagesArt. -Nr.: HY-17368S1CAS. Nr.: 194930-04-6Synonyms: (Rac)-ENA 713-d6 free base; (Rac)-SDZ-ENA 713-d6 free base(Rac)-Rivastigmine-d6 is a labelled racemic Rivastigmine. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.
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(rac)-Dobutamine-d6 hydrochloride
0 ImagesArt. -Nr.: HY-15746S1CAS. Nr.: 1246818-96-1(rac)-Dobutamine-d6 (hydrochloride) is a labelled racemic Dobutamine hydrochloride. Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion.
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Daurisoline-d11
0 ImagesArt. -Nr.: HY-N0221S2Synonyms: (R,R)-Daurisoline-d11Daurisoline-d11 is the deuterium labeled Daurisoline (HY-N0221). Daurisoline is a bis-benzylisoquinoline alkaloid that can be isolated from Menispermum dauricum and Rhizoma Menispermi. Daurisoline exerts a blocking effect on hERG and has antiarrhythmic effects. Daurisoline is a potent autophagy blocker that can be used for the research of cancer.
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RPR132595A-d3
0 ImagesArt. -Nr.: HY-132545SCAS. Nr.: 1217625-98-3Synonyms: NPC-d3RPR132595A-d3 is the deuterium labeled RPR132595A. RPR132595A is an active metabolite of Irinotecan (CPT-11), which is generated by cytochrome P-450 3A4 (CYP3A4) and finally excreted through urine.
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1-Iodonaphthalene-d7
0 ImagesArt. -Nr.: HY-W007608SCAS. Nr.: 1370362-69-81-Iodonaphthalene-d7 is the deuterium labeled 1-Iodonaphthalene (HY-W007608).
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2,2',3,4',5,6,6'-heptachloro-1,1'-biphenyl-13C12
0 ImagesArt. -Nr.: HY-W748321CAS. Nr.: 234432-91-82,2',3,4',5,6,6'-heptachloro-1,1'-biphenyl-13C12 is 13C labeled 2,2',3,4',5,6,6'-Heptachloro-1,1'-biphenyl.
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24,25-Dihydroxy Vitamin D2-d3
0 ImagesArt. -Nr.: HY-132383SCAS. Nr.: 118584-50-224,25-Dihydroxy Vitamin D2-d3 is the deuterium labeled 24,25-Dihydroxy Vitamin D2.
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2-Ethyl-3-methylpyrazine-d3
0 ImagesArt. -Nr.: HY-W012832SCAS. Nr.: 1335401-33-62-Ethyl-3-methylpyrazine-d3 is deuterated labeled 2-Ethyl-3-methylpyrazine.
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Diethyl adipate-d10
0 ImagesArt. -Nr.: HY-W716523Diethyl adipate-d10 is the deuterium labeled Diethyl adipate.
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Arprinocid-15N3
0 ImagesArt. -Nr.: HY-W104379SArprinocid-15N3 is 15N3-labeled Arprinocid (HY-W104379). Arprinocid is a purine analog with activity against murine Toxoplasma gondii.
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Mavacamten-d6
0 ImagesArt. -Nr.: HY-109037SCAS. Nr.: 2453251-18-6Synonyms: MYK461-d6; SAR439152-d6Mavacamten-d6 (MYK461-d6; SAR439152-d6) is deuterium labeled Mavacamten (HY-109037). Mavacamten (MYK461) is an orally active modulator of cardiac myosin, with IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively.
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2-Ethyl-3-methoxypyrazine-d5
0 ImagesArt. -Nr.: HY-W099906SCAS. Nr.: 3028868-72-3Synonyms: Pyrazine, 2-ethyl-3-methoxy-d52-Ethyl-3-methoxypyrazine-d5 is deuterated labeled 2-Ethyl-3-methoxypyrazine.
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15-Keto-prostaglandin E2-d4
0 ImagesArt. -Nr.: HY-113205S1CAS. Nr.: 2738376-85-515-Keto-prostaglandin E2-d4 is the d4 labeled 15-keto-Prostaglandin E2 (HY-113205). 15-keto-Prostaglandin E2 (15-keto-PGE2) is an endogenous PGE2 metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to the Cys259 residue of STAT3. 15-keto-Prostaglandin E2 binds to and stabilizes EP2 and EP4 receptors. 15-keto-Prostaglandin E2 inhibits the growth and progression of breast cancer cells. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth. 15-keto-Prostaglandin E2 disrupts glomerular vascularization during zebrafish development and reduces the surface area of the glomerular filtration barrier.
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Tenuazonic acid-(acetyl-13C2) (mixture of diastereomers) in methanol
0 ImagesArt. -Nr.: HY-152040SCAS. Nr.: 1486471-66-2Synonyms: 3-(Acetyl-13C2)-5-((S)-sec-butyl)-4-hydroxy-1,5-dihydro-2H-pyrrol-2-oneTenuazonic acid-(acetyl-13C2) (mixture of diastereomers) in methanol (3-(Acetyl-13C2)-5-((S)-sec-butyl)-4-hydroxy-1,5-dihydro-2H-pyrrol-2-one) is 13C labeled Tenuazonic acid-(acetyl) (mixture of diastereomers) in methanol.
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Ganglioside GM3-d7
0 ImagesArt. -Nr.: HY-114456SGanglioside GM3-d7 is deuterium labeled Ganglioside GM3. Ganglioside GM3 is a precursor of a-, b-, and c-series gangliosides, interacts with transmembrane receptors such as the epidermal growth factor and insulin receptors, and regulates receptor functions by creating a specialized lipid environment. Ganglioside GM3 is synthesized by GM3 synthase and can be used for the research of hypercholesterolemia.
