Mebeverine hydrochloride
Based on 1 Customer Validation
Mebeverine hydrochloride, a β-phenylethylamine derivative, is a musculotropic agent that potently blocks intestinal peristalsis. Mebeverine directly blocks voltage-operated sodium channels and inhibits intracellular calcium accumulation.
For research use only. We do not sell to patients.
- Purity: 99.85%
- CAS No.: 2753-45-9
- Formula: C25H36ClNO5
- Molecular Weight:466.01
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Mebeverine hydrochloride inhibits the α1 action by limiting the amount of available calcium mobilized on receptor stimulation of the smooth muscle cells of guinea-pig taenia caeci. Mebeverine (6×10-6 M) hydrochloride shows atropine-like properties by shifting to the right the concentration-response curve obtained with carbachol. The α1-receptor-induced hyperpolarization caused by adrenaline (3×10-6 M) in the presence of mebeverine declines after reaching an initial maximum. Mebeverine (6×10-5 M) hydrochloride causes a small hyperpolarization of the muscle cells (2.1 + 0.5 mV) and suppression of spike activity[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2753-45-9
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Appearance Solid
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Molecular Weight 466.01
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Formula C25H36ClNO5
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Color White to off-white
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SMILES
O=C(OCCCCN(CC)C(C)CC1=CC=C(OC)C=C1)C2=CC=C(OC)C(OC)=C2.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 155 mg/mL (332.61 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Annaházi A, et al. Role of antispasmodics in the treatment of irritable bowel syndrome. World J Gastroenterol. 2014;20(20):6031-6043. [Content Brief]
[2]. Den Hertog A, et al. Modification of alpha 1-receptor-operated channels by mebeverine in smooth muscle cells of guinea-pig taenia caeci. Eur J Pharmacol. 1987 Jun 26;138(3):367-74. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1459 mL | 10.7294 mL | 21.4588 mL | 53.6469 mL |
| 5 mM | 0.4292 mL | 2.1459 mL | 4.2918 mL | 10.7294 mL | |
| 10 mM | 0.2146 mL | 1.0729 mL | 2.1459 mL | 5.3647 mL | |
| 15 mM | 0.1431 mL | 0.7153 mL | 1.4306 mL | 3.5765 mL | |
| 20 mM | 0.1073 mL | 0.5365 mL | 1.0729 mL | 2.6823 mL | |
| 25 mM | 0.0858 mL | 0.4292 mL | 0.8584 mL | 2.1459 mL | |
| 30 mM | 0.0715 mL | 0.3576 mL | 0.7153 mL | 1.7882 mL | |
| 40 mM | 0.0536 mL | 0.2682 mL | 0.5365 mL | 1.3412 mL | |
| 50 mM | 0.0429 mL | 0.2146 mL | 0.4292 mL | 1.0729 mL | |
| 60 mM | 0.0358 mL | 0.1788 mL | 0.3576 mL | 0.8941 mL | |
| 80 mM | 0.0268 mL | 0.1341 mL | 0.2682 mL | 0.6706 mL | |
| 100 mM | 0.0215 mL | 0.1073 mL | 0.2146 mL | 0.5365 mL |
Mebeverine hydrochloride Related Classifications
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