2. Signaling Pathways
  3. Immunology/Inflammation
  4. CD3

CD3

Cluster of differentiation 3

CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with the T-cell receptor (TCR) and the CD3-zeta (ζ-chain) to generate an activation signal in T lymphocytes. The TCR, CD3-zeta, and the other CD3 molecules together constitute the TCR complex.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P992390
    IOR-T3
    		Ligand
    IOR-T3 is a monoclonal antibody targeting CD3, with biological activities related to T cell activation regulation. IOR-T3 uses its variable region to competitively engage surface CD3 on lymphocytes and trigger robust T cell proliferation and activation. IOR-T3 and its derivatives can be used in studies related to acute transplant rejection.
    IOR-T3
  • HY-P992401
    M802
    		Inhibitor
    M802 is an anti-HER2/CD3 bispecific antibody, with a Kd of 0.578 nM for human HER2 and a Kd of 71.2 nM for human CD3. M802 inhibits the PI3K/AKT and MAPK signaling pathways, suppresses tumor cell proliferation, activates caspase-3, and promotes tumor cell apoptosis (apoptosis). M802 recruits and activates CD3-positive immune cells, mediates cytotoxicity against HER2-positive tumor cells, and induces immune cells to secrete IFN-γ, TNF-α, IL-2 and IL-6. M802 exhibits anti-tumor efficacy in mice with gastric cancer xenografts. M802 can be used in research related to HER2-positive breast cancer, HER2-positive gastric cancer and other cancers. The recommended isotype control is human IgG1 kappa (HY-P99001).
    M802
  • HY-P992136
    Torutamig
    		Inhibitor
    Torutamig is a monoclonal antibody targeting TNFRSF17/BCMA/CD269&CD3E.
    Torutamig
  • HY-P990113
    Anti-Rat TCR gamma/delta Antibody (V65)
    		Inhibitor
    Anti-Rat TCR gamma/delta Antibody (V65) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to rat TCR gamma/delta. Anti-Rat TCR gamma/delta Antibody (V65) can deplete γδ T cells. Anti-Rat TCR gamma/delta Antibody (V65) can be used for the research of immunology.
    Anti-Rat TCR gamma/delta Antibody (V65)
  • HY-P99147
    Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6)
    		Inhibitor
    Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6) is an Armenian Hamster-derived IgG antibody inhibitor, targeting to mouse TCR V gamma 2. Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6) reacts with an epitope on the delta chain of the mouse Vγ2 TCR (V gamma 2 T cell receptor). Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6) can deplete γδ T cell. Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6) can be used for the researches of infection and immunology, such as herpes simplex virus-1 (HSV-1) infection.
    Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6)
  • HY-N10445
    Maydispenoid A
    Maydispenoid A is a potent immunosuppressor. Maydispenoid A can inhibit anti-CD3/anti-CD28 mAbs activated and lipopolysaccharide activated murine splenocyte proliferation.
    Maydispenoid A
  • HY-P992140
    Varzutamig
    		Inhibitor
    Varzutamig is a bispecific antibody targeting CD3E/ALB/EGFR.
    Varzutamig
Cat. No. Product Name / Synonyms Application Reactivity