2. Immunology/Inflammation
  3. CD3
  4. IOR-T3

IOR-T3 is a monoclonal antibody targeting CD3, with biological activities related to T cell activation regulation. IOR-T3 uses its variable region to competitively engage surface CD3 on lymphocytes and trigger robust T cell proliferation and activation. IOR-T3 and its derivatives can be used in studies related to acute transplant rejection.

For research use only. We do not sell to patients.

IOR-T3

IOR-T3 Chemical Structure

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IOR-T3 Related Antibodies

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Description

IOR-T3 is a monoclonal antibody targeting CD3, with biological activities related to T cell activation regulation. IOR-T3 uses its variable region to competitively engage surface CD3 on lymphocytes and trigger robust T cell proliferation and activation. IOR-T3 and its derivatives can be used in studies related to acute transplant rejection[1][2].

Species Reactivity

Human
In Vitro

IOR-T3 (1 h) potently binds to CD3 on human PBMCs, with equivalent antigen-binding capacity to its chimeric variants T3q and T3q(Ala=Ala)[1].
IOR-T3 (70-100 μg/mL; 7 days) does not inhibit the growth of human non-small-cell lung carcinoma H125 cells when used at 100 μg/mL for 7 days[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IOR-T3 Related Antibodies

Cell Proliferation Assay[2]

Cell Line: human non-small-cell lung carcinoma H125 cells
Concentration: 70, 90, 100 μg/mL
Incubation Time: 7 days
Result: Showed no inhibitory effect on H125 cell growth, with cell protein content remaining at 100% of control levels.
Gene ID

916  [NCBI]

Accession
Target

CD3E
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IOR-T3 Related Classifications

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The dilution calculator equation

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IOR-T3CD3Cluster of differentiation 3human PBMCshuman non-small-cell lung carcinoma cellsacute transplant rejectionhuman non-small-cell lung carcinoma H125 cellshuman peripheral blood mononuclear cellsIgG 2A monoclonal antibodyInhibitorinhibitorinhibit

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