CD3E - CD3 epsilon subunit of T-cell receptor complex Gene

Also Known as T3E; TCRE; IMD18; CD3epsilon

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 916

About CD3E

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,304,730-118,316,173 (from NCBI)

This gene has 6 transcripts (splice variants), 121 orthologues, 2 paralogues and is associated with 2 phenotypes. Biased expression in lymph node (RPKM 92.6), appendix (RPKM 45.9) and 9 other tissues.

Summary

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]

CD3E Products (1)

mRNA	Protein	Name
NM_000733.4	NP_000724.1	T-cell surface glycoprotein CD3 epsilon chain precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	12110186	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	14967045	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7761456	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23817958	GOA
involved in positive regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	12110186	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23817958	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of T cell receptor complex	IDA IDA: Inferred from direct assay	8176201	GOA
part of alpha-beta T cell receptor complex	IDA IDA: Inferred from direct assay	9485181	GOA
part of alpha-beta T cell receptor complex	IPI IPI: Inferred from physical interaction	31461748	GOA
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	11390434	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	11390434	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD3E Protein Structure

ITAM

0
100
207 a.a.

Protein Preferred Names	Protein Names
T-cell surface glycoprotein CD3 epsilon chain	CD3-epsilon

CD3E Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CD3E	P07766	ADAM33	Homo sapiens	Q08AM2	Validated Y2H	32296183
Intra	CD3E	P07766	PKMYT1	Homo sapiens	Q99640-2	Validated Y2H	32296183
Intra	CD3E	P07766	MUC15	Homo sapiens	Q8N387	Validated Y2H	32296183
Intra	CD3E	P07766	NCK1	Homo sapiens	P16333	Filamentous Phage	17617578
Intra	CD3E	P07766	NCK1	Homo sapiens	P16333	Anti Tag CoIP	17617578
Intra	CD3E	P07766	NCK1	Homo sapiens	P16333	Peptide Array	17617578
Intra	CD3E	P07766	NCK2	Homo sapiens	O43639	Filamentous Phage	17617578
Intra	CD3E	P07766	EPS8L1	Homo sapiens	Q8TE68	Pull Down	17617578
Intra	CD3E	P07766	EPS8L1	Homo sapiens	Q8TE68	NMR	18644376
Intra	CD3E	P07766	EPS8L1	Homo sapiens	Q8TE68	Peptide Array	17617578
Intra	CD3E	P07766	BNIP3	Homo sapiens	Q12983	Validated Y2H	32296183
Intra	CD3E	P07766	SYK	Homo sapiens	P43405	X-Ray Diffraction	9698567
Intra	CD3E	P07766	SYK	Homo sapiens	P43405	SPR	7761456

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD3E Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70434	CD3D-CD3E Heterodimer Protein, Human (HEK293, Fc-Flag&Fc-His)	P04234-1 (F22-A105)&P07766 (D23-D126)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70506	CD3 epsilon Protein, Human (HEK293, His)	P07766 (D23-D126)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70682	CD3 epsilon Protein, Human (104a.a, HEK293, Fc)	P07766 (D23-D126)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70824	CD3 epsilon 1-27 peptide Protein, Human (HEK293, mFc)	P07766 (Q22-T48)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72726	CD3D-CD3E Heterodimer Protein, Human (HEK293, His)	P04234-1 (F22-A105)&P07766 (D23-D126)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73498	CD3D-CD3E Heterodimer Protein, Human (HEK293, Flag-His)	P04234-1 (F22-A105)&P07766 (D23-D126)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72899	CD3E-CD3G Heterodimer Protein, Human (HEK293, Fc-Flag & mFc)	P07766/NP_000724 (D23-D126) & P09693/NP_000064 (Q23-S116)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77609	CD3E-CD3G Heterodimer Protein, Human (HEK293, His)	P07766 (D23-E120)&P09693 (Q23-Q106)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77610	CD3D-CD3E Heterodimer Protein, Human (HEK293, Fc)	P04234-1 (F22-A105)&P07766 (D23-D126)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77611	CD3E-CD3G Heterodimer Protein, Human (HEK293, Fc)	P07766 (D23-D126)&P09693 (Q23-S116)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77612	CD3D-CD3E Heterodimer Protein, Human (Biotinylated, HEK293, Fc-Avi)	P04234-1 (F22-A105)&P07766 (D23-D126)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77613	CD3E-CD3G Heterodimer Protein, Human (Biotinylated, HEK293, Fc-Avi)	P07766 (D23-D126)&P09693 (Q23-S116)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78089	CD3 epsilon 1-27 peptide Protein, Human (Biotinylated, HEK293, hFc-Avi)	P07766 (D23-T48)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78874	CD3 epsilon Protein, Human (Biotinylated, HEK293, His)	P07766/NP_000724.1 (D23-D126)	≥ 95%, as determined by reducing SDS-PAGE.

CD3E Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80598	CD3 epsilon Antibody (YA542)	WB, IHC-P, IP	Human
HY-P80598A	CD3 epsilon Antibody (YA542)(PBS only)	WB, IHC-P, IP	Human
HY-P83994	CD3 epsilon Antibody (YA3691)	WB, FC, ELISA	Human
HY-P83994A	CD3 epsilon Antibody (YA3691)(PBS only)	WB, FC, ELISA	Human
HY-P86568	CD3 epsilon Antibody (YA6260)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Immunodeficiency 18	IMD18 Cd3-Epsilon Deficiency Immunodeficiency 18, Scid Variant Cd3epsilon Deficiency Immunodeficiency 18, Severe Combined Immunodeficiency Variant Immunodeficiency, Type 18
T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta	T-B+ Scid Due To Cd3delta/Cd3epsilon/Cd3zeta
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9963	Blinatumomab	Inhibitor	98.78%	Unkown
HY-P99909	Elranatamab		98.74%	Unkown

Clinical Phase

Inhibitory Antibodies (12)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990932	Obrixtamig	Inhibitor	99.9%	Phase 3
HY-P99332	Visilizumab	Inducer	98.48%	Phase 3
HY-P990920	Gocatamig	Inhibitor	≥99.0%	Phase 2
HY-P990953	Zubotamig	Inhibitor	96.46%	Phase 2
HY-P99914	Emfizatamab	Activator	95.495%	Phase 2
HY-P991708	Olsutamig	Inhibitor	99.00%	Phase 2
HY-P99868	Duvortuxizumab		≥99.0%	Phase 1
HY-P99798	Pacanalotamab	Chemical	97.04%	Phase 1
HY-P991681	Emaretamig	Inhibitor	97.96%	Phase 1
HY-P990692	Ciduvectamig	Inhibitor	95.879%	Phase 1
HY-P991469	AMG-211	Inhibitor	/	Phase 1
HY-P991671	Anafiltamig	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02243	CD3E Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17021	Cd3e Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23464	Cd3e Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99896	Runimotamab		99.00%	Unkown
HY-P990903	Avitotamig	Inhibitor	95.98%	Unkown
HY-P991706	Nelvutamig	Inhibitor	97.76%	Unkown
HY-P991034	Trevotamig	Inhibitor	95.539%	Unkown
HY-P991686	Gamgertamig	Inhibitor	99.32%	Unkown
HY-P990714	Obertamig	Inhibitor	95.803%	Unkown
HY-P991461	AMG-424	Inhibitor	99.32%	Unkown
HY-P990939	Podentamig	Inhibitor	/	Unkown
HY-P992136	Torutamig	Inhibitor	/	Unkown
HY-P992145	Zeclantamig		/	Unkown
HY-P990698	Umizortamig		/	Unkown
HY-P991700	Lumivatamig	Inhibitor	97.24%	Unkown
HY-P992140	Varzutamig	Inhibitor	/	Unkown
HY-P991463	MS133	Inhibitor	/	Unkown
HY-P991552	AFM15	Inducer	/	Unkown
HY-P992061	Anti-Mouse CD3E Antibody (500A2)		/	Unkown
HY-P992370	HPN601	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CD3E	VGNC	VGNC:27029
Canis familiaris	CD3E	VGNC	VGNC:38955
Mus musculus	CD3E	MGD	MGI:88332
Felis catus	CD3E	VGNC	VGNC:81992
Rattus norvegicus	CD3E	RGD	RGD:1309222
Macaca mulatta	CD3E	VGNC	VGNC:70764
Others	CD3E	NCBI