MUC15 - mucin 15, cell surface associated Gene

Also Known as PAS3; MUC-15; PASIII

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 143662

About MUC15

Cytogenetic location: 11p14.2 Genomic coordinates (GRCh38): 11:26,559,032-26,572,263 (from NCBI)

This gene has 6 transcripts (splice variants), 509 orthologues and 14 paralogues. Biased expression in thyroid (RPKM 49.6), skin (RPKM 13.7) and 5 other tissues.

Summary

Predicted to be located in Golgi lumen and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

MUC15 Products (3)

mRNA Protein Name
NM_001135091.2 NP_001128563.1 mucin-15 isoform a
NM_001135092.2 NP_001128564.1 mucin-15 isoform c
NM_145650.4 NP_663625.2 mucin-15 isoform b precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mucin-15

MUC15 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MUC15 Q8N387 CD3E Homo sapiens P07766
Y2H Prey Pooling
32296183
Intra
MUC15 Q8N387 CD3E Homo sapiens P07766
Y2H Array
32296183
Intra
MUC15 Q8N387 LAMP2 Homo sapiens P13473-2
Y2H Pooling
32814053
Intra
MUC15 Q8N387 LAMP2 Homo sapiens P13473-2
Validated Y2H
32814053
Intra
MUC15 Q8N387 LAMP2 Homo sapiens P13473-2
Y2H Array
32814053
Intra
MUC15 Q8N387 SH3GLB1 Homo sapiens Q9Y371
Y2H Array
32814053
Intra
MUC15 Q8N387 SH3GLB1 Homo sapiens Q9Y371
Y2H Pooling
32814053
Intra
MUC15 Q8N387 SH3GLB1 Homo sapiens Q9Y371
Validated Y2H
32814053
Intra
MUC15 Q8N387 CNR2 Homo sapiens P34972
Y2H Array
32296183
Intra
MUC15 Q8N387 CNR2 Homo sapiens P34972
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MUC15 Proteins

Cat. No. Product Name Accession Purity
HY-P70172 Mucin-15/MUC15 Protein, Human (HEK293, His) AAH58007.1 (K24-T236) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Basosquamous Carcinoma

  • Carcinoma, Basosquamous

  • Basisquamous Cell Carcinoma

  • Basosquamous Cell Carcinoma

  • Metatypical Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08834 MUC15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21657 Muc15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28175 Muc15 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MUC15 RGD RGD:1589864
Canis familiaris MUC15 VGNC VGNC:43499
Felis catus MUC15 VGNC VGNC:63664
Mus musculus MUC15 MGD MGI:2442110
Bos taurus MUC15 VGNC VGNC:31759
Macaca mulatta MUC15 VGNC VGNC:74959
Others MUC15 NCBI