Drug Intermediate
Drug Iintermediate
Drug intermediates are used as raw materials for the production of bulk drugs, or they can refer to a material produced during synthesis of an API that must undergo further molecular change or processing before it becomes an API. Drug intermediates are hygienically formulated using high grade raw materials and they are used in the pharmaceutical and cosmetic industry[1][2].
References:
- [1]. Ma HC, et al. Homochiral Covalent Organic Framework for Catalytic Asymmetric Synthesis of a Drug Intermediate. J Am Chem Soc. 2020 Jul 22;142(29):12574-12578. [Content Brief]
- [2]. Ramachary D B, et al. Development of pharmaceutical drugs, drug intermediates and ingredients by using direct organo‐click reactions[J]. 2008.
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Drug Intermediate Related Products (4624)
Related Products (4624)
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1-Methyl-1H-indazol-5-amine
0 ImagesCat. No.: HY-69024CAS No.: 50593-24-31-Methyl-1H-indazol-5-amine is a drug intermediate that can be used for the synthesis of TRPM5 agonists.
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2,6-Diiodo-BODIPY 493/503
0 ImagesCat. No.: HY-W075603CAS No.: 1031443-55-6Synonyms: 2,6-Diiodo-Pyrromethene 5462,6-Diiodo-BODIPY 493/503 (2,6-Diiodo-Pyrromethene 546) is a 2,6-diiodo-substituted BODIPY intermediate that can be used to synthesize dual-organelle-targeted BODIPY-cyanostilbene fluorophores. 2,6-Diiodo-BODIPY 493/503 is applicable to research related to fluorescent dye synthesis.
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4-Biphenylsulfonyl chloride
0 Images4-Biphenylsulfonyl chloride is a synthetic intermediate that participates in the sulfonamide formation reaction to synthesize antiproliferative compounds. The derivatives of 4-Biphenylsulfonyl chloride inhibit human head and neck squamous cell carcinoma (HNSCC) cells by increasing PTEN expression and inhibiting the PI3K/Akt/mTOR pathway. 4-Biphenylsulfonyl chloride can be used in the development of anticancer drugs for HNSCC.
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4-Bromo-2,6-difluorobenzaldehyde
0 Images4-Bromo-2,6-difluorobenzaldehyde is a halogenated aromatic aldehyde and also a synthetic intermediate. 4-Bromo-2,6-difluorobenzaldehyde can be used for the synthesis of GDC-9545 (HY-109176), a selective estrogen receptor degrader and antagonist[1][2].
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6-Bromo-1H-indazole
0 Images6-Bromo-1H-indazole is an indazole derivative that serves as an intermediate for research related to organic synthesis. 6-Bromo-1H-indazole acts as a building block for the preparation of PI3Kδ inhibitors, and also functions as a synthetic intermediate for the preparation of colchicine site-targeted tubulin polymerization inhibitors[1][2].
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(R)-Tetrahydrofuran-2-carboxylic acid
0 ImagesSynonyms: (R)-(+)-Tetrahydrofuran-2-carboxylic acid(R)-Tetrahydrofuran-2-carboxylic acid is a chiral building block for Faropenem (HY-A0035). Faropenem is a clinically effective non-natural β-lactam antibiotic.
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Tricyclohexylphosphonium tetrafluoroborate
0 ImagesTricyclohexylphosphonium tetrafluoroborate is an intermediate. Tricyclohexylphosphonium tetrafluoroborate can be used to synthesize anticancer agents (Compounds 7a, 7e). Tricyclohexylphosphonium tetrafluoroborate can be used in the research of leukemia, lung cancer, liver cancer, breast cancer and colon cancer.
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2-Bromo-4'-hydroxyacetophenone
0 Images2-Bromo-4'-hydroxyacetophenone is a PTP1B inhibitor with a Ki value of 42 μM. 2-Bromo-4'-hydroxyacetophenone is also an intermediate. 2-Bromo-4'-hydroxyacetophenone can be used in the synthesis of LXRα/β antagonists. 2-Bromo-4'-hydroxyacetophenone can be used in research on hematological diseases.
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2-Acetylfuran
0 ImagesSynonyms: 2-Furyl methyl ketone2-Acetylfuran (2-Furyl methyl ketone), an important flavour compound or intermediate in foods, is isolated from essential oils, sweet corn products, fruits and flowers. 2-Acetylfuran also can be formed from glucose and glycine by Maillard reaction. 2-Acetylfuran can be used to synthesis Cefuroxime. 2-acetylfuran can be used in the synthesis of reagents with antiamoebic activity.
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Cyclomarin monomer-1
0 ImagesCat. No.: HY-P11497Cyclomarin monomer-1 (Compound 5), a cyclomarin monomer, is a pre-dimerization precursor that can form Homo-BacPROTACs targeting the degradation of ClpC1. Cyclomarin monomer-1 binds to the Mtb ClpC1 protein with a KD of 3.5 nM. The MIC of Cyclomarin monomer-1 against the Mtb H37Rv standard strain is 1.6 μM. Cyclomarin monomer-1 can be used as a key intermediate in the development of Homo-BacPROTACs.
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4,6-Dichloropyrimidin-5-amine
0 Images4,6-Dichloropyrimidin-5-amine is a pyrimidine derivative and synthetic intermediate. 4,6-Dichloropyrimidin-5-amine can be used for the preparation of Zika virus methyltransferase inhibitors, purine analogs and related derivatives.
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AN-12-H5 intermediate-1
0 ImagesSynonyms: (2S,4S)-1-tert-butyl 2-methyl-4-hydroxypiperidine-1,2-dicarboxylateAN-12-H5 intermediate-1 ((2S,4S)-1-tert-butyl 2-methyl-4-hydroxypiperidine-1,2-dicarboxylate) is an intermediate of the viral inhibitor AN-12-H5 (HY-120900) and can be used to synthesize Antibody-Drug Conjugates (ADCs).
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(S)-2-(3-Bromophenyl)propanoic acid
0 Images(S)-2-(3-Bromophenyl)propanoic acid is a drug intermediate for synthesis of various active compounds.
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tert-Butyl (2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)carbamate
0 Imagestert-Butyl (2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)carbamate is a drug intermediate for synthesis of various active compounds.
