4,6-Dichloropyrimidin-5-amine
Based on 1 Customer Validation
4,6-Dichloropyrimidin-5-amine is a pyrimidine derivative and synthetic intermediate. 4,6-Dichloropyrimidin-5-amine can be used for the preparation of Zika virus methyltransferase inhibitors, purine analogs and related derivatives.
For research use only. We do not sell to patients.
- Purity: 99.94%
- CAS No.: 5413-85-4
- Formula: C4H3Cl2N3
- Molecular Weight:164.00
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-W018744
4-Amino-2,6-dichloropyrimidine -
HY-41340
2-Aminopyrimidine -
HY-W008137
5-Bromo-2-fluoropyrimidine -
HY-W008017
5-Bromopyrimidine -
HY-34531
4,6-Dichloro-2-methylpyrimidine -
HY-30139
4-Amino-2-chloropyrimidine -
HY-I0093
4,6-Dichloro-2-(propylthio)pyrimidin-5-amine -
HY-60351
5-Aminopyrimidine -
HY-34490
4-Bromoisoquinoline -
HY-41340R
2-Aminopyrimidine (Standard) -
HY-W006265R
(4-Amino-2-methyl-5-pyrimidinyl)methanol (Standard)
Biological Activity
Description
In Vitro
4,6-Dichloropyrimidin-5-amine (2 equiv.; 6 days heated at 105°C, 5 days stirred at room temperature, 4 h stirred at room temperature) serves as a key precursor in the synthesis of 6-chloropurine derivatives 1b-15b via a two-step condensation and cyclization reaction sequence[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 5413-85-4
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Appearance Solid
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Molecular Weight 164.00
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Formula C4H3Cl2N3
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Color Off-white to light brown
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SMILES
ClC1=C(N)C(Cl)=NC=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (609.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (288 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.0976 mL | 30.4878 mL | 60.9756 mL | 152.4390 mL |
| 5 mM | 1.2195 mL | 6.0976 mL | 12.1951 mL | 30.4878 mL | |
| 10 mM | 0.6098 mL | 3.0488 mL | 6.0976 mL | 15.2439 mL | |
| 15 mM | 0.4065 mL | 2.0325 mL | 4.0650 mL | 10.1626 mL | |
| 20 mM | 0.3049 mL | 1.5244 mL | 3.0488 mL | 7.6220 mL | |
| 25 mM | 0.2439 mL | 1.2195 mL | 2.4390 mL | 6.0976 mL | |
| 30 mM | 0.2033 mL | 1.0163 mL | 2.0325 mL | 5.0813 mL | |
| 40 mM | 0.1524 mL | 0.7622 mL | 1.5244 mL | 3.8110 mL | |
| 50 mM | 0.1220 mL | 0.6098 mL | 1.2195 mL | 3.0488 mL | |
| 60 mM | 0.1016 mL | 0.5081 mL | 1.0163 mL | 2.5407 mL | |
| 80 mM | 0.0762 mL | 0.3811 mL | 0.7622 mL | 1.9055 mL | |
| 100 mM | 0.0610 mL | 0.3049 mL | 0.6098 mL | 1.5244 mL |
4,6-Dichloropyrimidin-5-amine Related Classifications
HY-W001987 Related Classifications
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Keywords
- 4,6-Dichloropyrimidin-5-amine
- 5413-85-4
- Biochemical Assay Reagents
- Drug Intermediate
- 6-chloropurine derivatives
- synthetic intermediate
- 6-chloropurine nucleobase derivatives
- condensation
- pyrimidine derivative
- arylpurine-based Zika virus methyltransferase inhibitors
- cyclization reaction
- 6,8,9-trisubstituted purine analogs
- chlorinated pyrimidine intermediate
- Inhibitor
- inhibitor
- inhibit