Cyclomarin monomer-1

Cat. No.: HY-P11497 Purity: 97.77%: Data Sheet
COA

SDS
Handling Instructions
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Cyclomarin monomer-1 (Compound 5), a cyclomarin monomer, is a pre-dimerization precursor that can form Homo-BacPROTACs targeting the degradation of ClpC1. Cyclomarin monomer-1 binds to the Mtb ClpC1 protein with a K_D of 3.5 nM. The MIC of Cyclomarin monomer-1 against the Mtb H37Rv standard strain is 1.6 μM. Cyclomarin monomer-1 can be used as a key intermediate in the development of Homo-BacPROTACs.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Cyclomarin monomer-1 Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

941.17

Formula

C₅₁H₇₂N₈O₉

Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (106.25 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0625 mL	5.3125 mL	10.6251 mL
5 mM	0.2125 mL	1.0625 mL	2.1250 mL
10 mM	0.1063 mL	0.5313 mL	1.0625 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.24%

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Data Sheet (281 KB) SDS (252 KB)

COA (266 KB)

Handling Instructions (2659 KB)

References

[1]. Junk L, et al. Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria. Nat Commun. 2024 Mar 5;15(1):2005 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0625 mL	5.3125 mL	10.6251 mL	26.5627 mL
	5 mM	0.2125 mL	1.0625 mL	2.1250 mL	5.3125 mL
	10 mM	0.1063 mL	0.5313 mL	1.0625 mL	2.6563 mL
	15 mM	0.0708 mL	0.3542 mL	0.7083 mL	1.7708 mL
	20 mM	0.0531 mL	0.2656 mL	0.5313 mL	1.3281 mL
	25 mM	0.0425 mL	0.2125 mL	0.4250 mL	1.0625 mL
	30 mM	0.0354 mL	0.1771 mL	0.3542 mL	0.8854 mL
	40 mM	0.0266 mL	0.1328 mL	0.2656 mL	0.6641 mL
	50 mM	0.0213 mL	0.1063 mL	0.2125 mL	0.5313 mL
	60 mM	0.0177 mL	0.0885 mL	0.1771 mL	0.4427 mL
	80 mM	0.0133 mL	0.0664 mL	0.1328 mL	0.3320 mL
	100 mM	0.0106 mL	0.0531 mL	0.1063 mL	0.2656 mL