4-Bromo-2,6-difluorobenzaldehyde
Based on 1 Customer Validation
4-Bromo-2,6-difluorobenzaldehyde is a halogenated aromatic aldehyde and also a synthetic intermediate. 4-Bromo-2,6-difluorobenzaldehyde can be used for the synthesis of GDC-9545 (HY-109176), a selective estrogen receptor degrader and antagonist[1][2].
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 537013-51-7
- Formula: C7H3BrF2O
- Molecular Weight:221.00
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
GDC-9545 is a potent, orally bioavailable selective estrogen receptor antagonist and degrader, which is used for ER+ breast cancer research[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 537013-51-7
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Appearance Solid
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Molecular Weight 221.00
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Formula C7H3BrF2O
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Color White to light yellow
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SMILES
O=CC1=C(F)C=C(Br)C=C1F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (452.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
References
[1]. Zhang G, et al. Discovery of an Orally Bioavailable and Brain Penetrant Selective Estrogen Receptor Degrader. Journal of medicinal chemistry. 2025 Jun 12;68(11):11990-12003. [Content Brief]
[2]. Liang J, et al. GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer. Journal of medicinal chemistry. 2021 Aug 26;64(16):11841-11856. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.5249 mL | 22.6244 mL | 45.2489 mL | 113.1222 mL |
| 5 mM | 0.9050 mL | 4.5249 mL | 9.0498 mL | 22.6244 mL | |
| 10 mM | 0.4525 mL | 2.2624 mL | 4.5249 mL | 11.3122 mL | |
| 15 mM | 0.3017 mL | 1.5083 mL | 3.0166 mL | 7.5415 mL | |
| 20 mM | 0.2262 mL | 1.1312 mL | 2.2624 mL | 5.6561 mL | |
| 25 mM | 0.1810 mL | 0.9050 mL | 1.8100 mL | 4.5249 mL | |
| 30 mM | 0.1508 mL | 0.7541 mL | 1.5083 mL | 3.7707 mL | |
| 40 mM | 0.1131 mL | 0.5656 mL | 1.1312 mL | 2.8281 mL | |
| 50 mM | 0.0905 mL | 0.4525 mL | 0.9050 mL | 2.2624 mL | |
| 60 mM | 0.0754 mL | 0.3771 mL | 0.7541 mL | 1.8854 mL | |
| 80 mM | 0.0566 mL | 0.2828 mL | 0.5656 mL | 1.4140 mL | |
| 100 mM | 0.0452 mL | 0.2262 mL | 0.4525 mL | 1.1312 mL |
4-Bromo-2,6-difluorobenzaldehyde Related Classifications
HY-Y1747 Related Classifications
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- 4-Bromo-2,6-difluorobenzaldehyde
- 537013-51-7
- Drug Intermediate
- selective estrogen receptor degraders
- estrogen receptor
- toluene
- Pictet-Spengler reaction
- 1H-indol-3-yl
- halogenated aromatic aldehyde
- (R)-3-((1-(1H-indol-3-yl)propan-2-yl)amino)-2,2-difluoropropan-1-ol
- (R)-N-(1-(1H-indol-3-yl)propan-2-yl)bicyclo[1.1.1]pentan-1-amine
- Inhibitor
- inhibitor
- inhibit