2-Bromo-5-fluoropyridine
Based on 1 Customer Validation
2-Bromo-5-fluoropyridine acts as a bromofluoropyridine starting material and an azaaryl halide coupling partner. 2-Bromo-5-fluoropyridine participates in an oxygen-promoted, ligand-free Pd (OAc)2-catalyzed Suzuki reaction, reacting with arylboronic acids to produce 5-fluoro-2-aryl-substituted pyridine derivatives. 2-Bromo-5-fluoropyridine can be used to synthesize 5-fluoro-2-(4-(methylsulfonyl) phenyl) pyridine, an intermediate of the GPR119 agonist GSK1292263A.
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- 純度 : 99.46%
- CAS 番号: 41404-58-4
- 分子式: C5H3BrFN
- 分子量:175.99
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保管条件:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
体外実験
2-Bromo-5-fluoropyridine undergoes a high-yield Suzuki-Miyaura cross-coupling with (4-(methylsulfonyl)phenyl)boronic acid to form 5-fluoro-2-(4-(methylsulfonyl)phenyl)pyridine in 89.9% yield under optimized palladium-catalyzed conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
化学情報
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CAS 番号 41404-58-4
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性状 <30°C Solid,>31°C Liquid
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分子量 175.99
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分子式 C5H3BrFN
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Color Colorless to off-white
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SMILES
FC1=CN=C(Br)C=C1
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別名
2-ブロモ-5-フルオロピリジン
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (568.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (14.21 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (14.21 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (280 KB)
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SDS (393 KB)
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- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.6821 mL | 28.4107 mL | 56.8214 mL | 142.0535 mL |
| 5 mM | 1.1364 mL | 5.6821 mL | 11.3643 mL | 28.4107 mL | |
| 10 mM | 0.5682 mL | 2.8411 mL | 5.6821 mL | 14.2054 mL | |
| 15 mM | 0.3788 mL | 1.8940 mL | 3.7881 mL | 9.4702 mL | |
| 20 mM | 0.2841 mL | 1.4205 mL | 2.8411 mL | 7.1027 mL | |
| 25 mM | 0.2273 mL | 1.1364 mL | 2.2729 mL | 5.6821 mL | |
| 30 mM | 0.1894 mL | 0.9470 mL | 1.8940 mL | 4.7351 mL | |
| 40 mM | 0.1421 mL | 0.7103 mL | 1.4205 mL | 3.5513 mL | |
| 50 mM | 0.1136 mL | 0.5682 mL | 1.1364 mL | 2.8411 mL | |
| 60 mM | 0.0947 mL | 0.4735 mL | 0.9470 mL | 2.3676 mL | |
| 80 mM | 0.0710 mL | 0.3551 mL | 0.7103 mL | 1.7757 mL | |
| 100 mM | 0.0568 mL | 0.2841 mL | 0.5682 mL | 1.4205 mL |
2-Bromo-5-fluoropyridine 関連分類
HY-32748 関連分類
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Keywords
- 2-Bromo-5-fluoropyridine
- 41404-58-4
- Biochemical Assay Reagents
- Drug Intermediate
- 5-fluoro-2-aryl-substituted pyridine derivatives
- 5-fluoro-2-(4-(methylsulfonyl)phenyl)pyridine
- Pd(OAc)2
- (4-(methylsulfonyl)phenyl)boronic acid
- GSK1292263A
- Suzuki reactions
- GPR119
- Suzuki-Miyaura cross-coupling
- aryl boronic acids
- Inhibitor
- inhibitor
- inhibit