41404-58-4
Chemical Structure
2-Bromo-5-fluoropyridine
- CAS No.: 41404-58-4
- Formula:C5H3BrFN
- Molecular Weight:175.99
IUPAC Name: 2-bromo-5-fluoropyridine
InChIKey: UODINHBLNPPDPD-UHFFFAOYSA-N
SMILES: FC1=CN=C(Br)C=C1
Biological Activity: 2-Bromo-5-fluoropyridine acts as a bromofluoropyridine starting material and an azaaryl halide coupling partner. 2-Bromo-5-fluoropyridine participates in an oxygen-promoted, ligand-free Pd (OAc)2-catalyzed Suzuki reaction, reacting with arylboronic acids to produce 5-fluoro-2-aryl-substituted pyridine derivatives. 2-Bromo-5-fluoropyridine can be used to synthesize 5-fluoro-2-(4-(methylsulfonyl) phenyl) pyridine, an intermediate of the GPR119 agonist GSK1292263A[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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2-Bromo-5-fluoropyridine | 99.46% | 2-Bromo-5-fluoropyridine acts as a bromofluoropyridine starting material and an azaaryl halide coupling partner. 2-Bromo-5-fluoropyridine participates in an oxygen-promoted, ligand-free Pd (OAc)2-catalyzed Suzuki reaction, reacting with arylboronic acids to produce 5-fluoro-2-aryl-substituted pyridine derivatives. 2-Bromo-5-fluoropyridine can be used to synthesize 5-fluoro-2-(4-(methylsulfonyl) phenyl) pyridine, an intermediate of the GPR119 agonist GSK1292263A. | ||||||||||||||||||||
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References
- [1]. Matsuoka R T, et al. Development of Large-Scale Routes to Potent GPR119 Receptor Agonists. Organic Process Research & Development, 2016, 20(8): 1469-1475.
- [2]. Liu C, et al. A fast and oxygen-promoted protocol for the ligand-free Suzuki reaction of 2-halogenated pyridines in aqueous media. Chemical communications (Cambridge, England). 2009 Nov 07.
