2. Signaling Pathways
  3. Immunology/Inflammation
  4. FAP

FAP

Fibroblast activation protein

Fibroblast activation protein (FAP) is a cell-surface serine protease that acts on various hormones and extracellular matrix components. FAP is highly upregulated in a wide variety of cancers, and is often used as a marker for pro-tumorigenic stroma.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-164316A
    FT-FAPI-12_9 TFA
    		99.48%
    FT-FAPI-12_9 TFA is a FAP ligand that can be used to synthesize FAPI-46, a radiotracer targeting FAP.
    FT-FAPI-12_9 TFA
  • HY-164364B
    DOTAGA.(SA.FAPi)2 analogue TFA
    		Inhibitor 99.38%
    DOTAGA.(SA.FAPi)2 analogue TFA is a DOTAGA.(SA.FAPi)2 TFA (HY-164364A) analogue, in which the ligand and the chelator are identical to those of DOTAGA.(SA.FAPi)2 TFA. DOTAGA.(SA.FAPi)2 TFA is a potent dimeric fibroblast-activation protein inhibitor (FAPi).
    DOTAGA.(SA.FAPi)2 analogue TFA
  • HY-158326
    FAP-IN-4
    		Inhibitor
    FAP-IN-4 (Comp 10) is a fibroblast activation protein (FAP) inhibitor and a 18F-labeled PET tracer targeting FAP. FAP-IN-4 can be used for cancer research.
    FAP-IN-4
  • HY-D2281
    FAP Ligand 2
    FAP Ligand 2, a FAPI-46 derivative, is a specific fibroblast activation protein (FAP)-targeted tracer. FAP Ligand 2 exhibits good tumor uptake and acts as a promising molecular tracer for FAP tumor imaging.
    FAP Ligand 2
  • HY-177459
    DOTA-2P(FAPI)2
    		Inhibitor
    DOTA-2P(FAPI)2 is a dimeric FAP (fibroblast activation protein) that can be used as a PET imaging agent and a tracer for tumor therapy.
    DOTA-2P(FAPI)2
  • HY-159768A
    DOTAGA.Glu.(FAPi)2
    		Ligand
    DOTAGA.Glu.(FAPi) 2 is a FAPI homodimer in which a central glutamic acid (Glu) linker connects FAPI and a chelator. Radiolabeled with gallium-68, lutetium-177 or terbium-161, DOTAGA.Glu.(FAPi) 2 is applicable to FAP-positive cancer PET imaging studies. DOTAGA.Glu.(FAPi) 2 is suitable for research related to prostate adenocarcinoma and recurrent glioblastoma multiforme.
    DOTAGA.Glu.(FAPi)2
  • HY-175612
    DOTA-ALB-01
    		Ligand
    DOTA-ALB-01 is an albumin-bound FAP inhibitor (FAPI) ligand. DOTA-ALB-01 labeled with 68Ga or 177Lu has a high FAP-binding affinity and enhanced tumor uptake and retention. DOTA-ALB-01 can be used for PET/CT and SPECT/CT imaging of cancers, especially late-stage cancers.
    DOTA-ALB-01
  • HY-128642A
    FAPI-2 TFA
    		98.05%
    FAPI-2 TFA is a quinoline-based fibroblast activation protein (FAP)-targeting ligand that can be labeled as 68Ga-FAPI-2 and used as a PET tracer for cancer diagnosis. FAPI-2 TFA has advantages such as fast tracer kinetics, no need for fasting preparation, and being unaffected by blood glucose.
    FAPI-2 TFA
  • HY-161262
    SB03178
    		Inhibitor
    SB03178 is a fibroblast activation protein-alpha (FAP) inhibitor. SB03178 can be conjugated with DOTA and can be used for cancer research.
    SB03178
  • HY-149860
    FAP-IN-1
    		Inhibitor
    FAP-IN-1 is a fibroblast activation protein (FAP) inhibitor with an IC50 value of 3.3 nM. FAP-IN-1 can be used for the research of cancer.
    FAP-IN-1
  • HY-146180
    FSDD0I
    FSDD0I is an albumin-binding fibroblast activation protein (FAP) ligand. FSDD0I can be labeled with 68Ga and 177Lu for single photon emission computed tomography (SPECT) imaging.
    FSDD0I
  • HY-159934
    QI-18
    		Inhibitor
    QI-18 is a fibroblast activation protein (FAP) inhibitor with the IC50 of 0.50 nM, which is a 6.5-fold increase in potency over that of UAMC-1110 (HY-100684，IC50 of 3.25 nM). QI-18 can be used to synthesize high tumor selectivity and high dose radiotracers for the diagnosis and study of tumors.
    QI-18
  • HY-173319
    FAP-IN-5
    		Inhibitor
    FAP-IN-5 (Compound 4a) is an FAP inhibitor with an IC50 of 1.7 nM. FAP-IN-5 can be used in the research of tumor positron emission tomography (PET) imaging.
    FAP-IN-5
  • HY-174421
    FAPI-JNU
    		Ligand
    FAPI-JNU is a molecule targeting fibroblast activation protein (FAP). FAPI-JNU specifically binds to FAP highly expressed in the tumor microenvironment, and uses radionuclides [68Ga]Ga or [177Lu]Lu to achieve tumor imaging diagnosis. [177Lu]Lu−FAPI−JNU can effectively target and inhibit tumor growth in tumor-bearing mice. FAPI-JNU is promising for research of FAP-positive tumors (such as various solid tumors).
    FAPI-JNU
  • HY-146181
    FSDD1I
    FSDD1I is an albumin-binding fibroblast activation protein (FAP) ligand. FSDD1I can be labeled with 68Ga and 177Lu for single photon emission computed tomography (SPECT) imaging.
    FSDD1I
  • HY-182434
    CL 118326
    		Antagonist
    CL 118326 is a potent, selective, competitive inhibitor of mammalian pancreatic phospholipase A2 (PLA2) and a weak antagonist of platelet-activating factor receptor (PAF receptor). CL 118326 competitively inhibits mammalian pancreatic PLA2 (porcine: IC50 = 1.55 μg/mL), and shows no activity against snake venom or bee venom PLA2. CL 118326 inhibits PAF-induced and thrombin-induced platelet aggregation, as well as the release of leukotriene (LTC4) and histamine from basophil-enriched leukocytes. CL 118326 can be used for research on inflammation and allergic reactions.
    CL 118326
  • HY-P3392C
    Zilganersen sodium scrambled negative control
    		Inhibitor
    Zilganersen sodium scrambled negative control is the sequence scrambled negative control of Zilganersen sodium.
    Zilganersen sodium scrambled negative control
  • HY-103323
    Fas C-Terminal Tripeptide
    		Inhibitor
    Fas C-Terminal Tripeptide is a C-terminal tripeptide of Fas. Fas C-Terminal Tripeptide shows the inhibitory effect on Fas/FAP-1 binding.
    Fas C-Terminal Tripeptide
  • HY-172137
    FAPI-FUSCC-07
    		Ligand
    FAPI-FUSCC-07 is a targeted probe for fibroblast activation protein (FAP), exhibiting high affinity binding to FAP for applications in molecular imaging, tumor diagnosis, and radiotherapy.
    FAPI-FUSCC-07
  • HY-P3441
    3BP-4089
    		Inhibitor 99.27%
    3BP-4089 is a highly efficient fibroblast activation protein (FAP) targeting peptide. 3BP-4089 is often conjugated with radionuclides for tumor diagnosis and research.
    3BP-4089
Cat. No. Product Name / Synonyms Application Reactivity