DOTAGA.Glu.(FAPi)2 

DOTAGA.Glu.(FAPi) 2 is a FAPI homodimer in which a central glutamic acid (Glu) linker connects FAPI and a chelator. Radiolabeled with gallium-⁶⁸, lutetium-¹⁷⁷ or terbium-¹⁶¹, DOTAGA.Glu.(FAPi) 2 is applicable to FAP-positive cancer PET imaging studies. DOTAGA.Glu.(FAPi) 2 is suitable for research related to prostate adenocarcinoma and recurrent glioblastoma multiforme^[1][2].

^68/natGa-DOTAGA.Glu.(FAPi)2 and ^177/natLu-DOTAGA.Glu.(FAPi)2 (0.1-10 nM) bind to FAP⁺ CAFs with high affinity, with K_d values of 0.8 nM and 0.7 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

[177Lu]LuDOTAGA.Glu.(FAPi)2 (600 pmol; intravenous injection) exhibits slightly longer initial and terminal half-lives than [¹⁷⁷Lu]Lu-DO3A.Glu.(FAPI)2 in healthy nude mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1432.43

C₆₆H₈₁F₄N₁₅O₁₇

2882922-68-9

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Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bilinska A, et al. Preclinical evaluation of DOTAGA.Glu.(FAPI)₂ and DO3A.Glu.(FAPI)₂ as theranostics with human dosimetry extrapolation to lutetium-177 and terbium-161 analogs. Eur J Nucl Med Mol Imaging. 2026;53(3):1887-1901.  [Content Brief]

  [2]. Ballal S, et al. [¹⁷⁷Lu]Lu-DOTAGA.Glu.(FAPi)₂ Radionuclide Therapy: a New Treatment Option for Patients with Glioblastoma Multiforme. Nucl Med Mol Imaging. 2024;58(1):32-34.  [Content Brief]