3093894-38-0
3093894-38-0
Chemical Structure
QI-18
- CAS. Nr.: 3093894-38-0
- Formula:C31H27F2N7O7
- Molecular Weight:647.59
InChIKey: LOLDJRGTEJMCTJ-CPJSRVTESA-N
SMILES: OC(CNC([C@H](CC1=CC=C(C#N)C=C1)NC(COC2=CC=C(N=CC=C3C(NCC(N4CC(F)(F)C[C@H]4C#N)=O)=O)C3=C2)=O)=O)=O
Biological Activity: QI-18 is a fibroblast activation protein (FAP) inhibitor with the IC50 of 0.50 nM, which is a 6.5-fold increase in potency over that of UAMC-1110 (HY-100684，IC50 of 3.25 nM). QI-18 can be used to synthesize high tumor selectivity and high dose radiotracers for the diagnosis and study of tumors[1].
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QI-18 | QI-18 is a fibroblast activation protein (FAP) inhibitor with the IC50 of 0.50 nM, which is a 6.5-fold increase in potency over that of UAMC-1110 (HY-100684，IC50 of 3.25 nM). QI-18 can be used to synthesize high tumor selectivity and high dose radiotracers for the diagnosis and study of tumors. | |||||||||||||||||||||
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References
Keywords
