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Cat. No.: HY-177459

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DOTA-2P(FAPI)2

DOTA-2P(FAPI)2 is a dimeric FAP (fibroblast activation protein) that can be used as a PET imaging agent and a tracer for tumor therapy.

For research use only. We do not sell to patients.

Formula: C₉₂H₁₃₂F₄N₂₂O₂₂
Molecular Weight:1974.16

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

DOTA-2P(FAPI)2 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

DOTA-2P(FAPI)2 is a dimeric FAP (fibroblast activation protein) that can be used as a PET imaging agent and a tracer for tumor therapy^[1].

Chemical Information

Molecular Weight 1974.16
Formula C₉₂H₁₃₂F₄N₂₂O₂₂
SMILES

O=C(C1=CC=NC(C=C2)=C1C=C2N(C)CCCN(CC3)CCN3C(COCCOCCOCCNC(CCC(N[C@@H](CCCCNC(CN(CCN(CC4)CC(O)=O)CCN(CCN4CC(O)=O)CC(O)=O)=O)C(NCCOCCOCCOCC(N5CCN(CCCN(C)C(C=C6)=CC7=C6N=CC=C7C(NCC(N8CC(F)(F)C[C@H]8C#N)=O)=O)CC5)=O)=O)=O)=O)=O)NCC(N(CC9(F)F)[C@@H](C9)C#N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhao L, Niu B, Fang J, et al. Synthesis, Preclinical Evaluation, and a Pilot Clinical PET Imaging Study of 68Ga-Labeled FAPI Dimer. J Nucl Med. 2022;63(6):862-868.

[2]. Zhao L, et al. Synthesis, Preclinical Evaluation, and a Pilot Clinical PET Imaging Study of 68Ga-Labeled FAPI Dimer. J Nucl Med. 2022 Jun;63(6):862-868. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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