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Art. -Nr.: HY-77278

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25-Hydroxytachysterol3

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25-Hydroxytachysterol3 is the metabolite of Vitamin D3 (HY-15398). 25-Hydroxytachysterol3 inhibits the proliferation of epidermal keratinocytes and dermal fibroblasts, stimulates the expression of differentiation- and antioxidant-related genes in keratinocytes. 25-Hydroxytachysterol3 activates vitamin D receptor (VDR) and aryl hydrocarbon receptor (AhR), liver X receptor α/β (LXR α/β) and peroxisome proliferator-activated receptor γ (PPARγ), stimulates the expression of CYP24A1.

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Reinheit: 98.07%
CAS. Nr.: 39932-44-0
Formel: C₂₇H₄₄O₂
Molecular Weight:400.64

Speicherung:

-80°C, protect from light, stored under nitrogen

25-Hydroxytachysterol3 Chemical Structure

CAS. Nr.: 39932-44-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
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Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

PPARγ

Alle PPAR Isoform-spezifische Produkte anzeigen :

In Vitro

25-Hydroxytachysterol3 (25(OH)T3) (0.1-100 μM; 24-48 h) inhibits the proliferation of epidermal keratinocytes and dermal fibroblasts^[1].
25-Hydroxytachysterol3 (0.1-100 μM; 24 h) stimulates the expression of genes involved in keratinocyte differentiation and antioxidative pathways^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Primary human epidermal keratinocytes or dermal fibroblasts.
Concentration:

0.1 μM, 1 μM, 10 μM, 100 μM
Incubation Time:

24 h or 48 h
Result:

Inhibited the proliferation of epidermal keratinocytes and dermal fibroblasts.

RT-PCR^[1]

Cell Line:

Primary human epidermal keratinocytes or dermal fibroblasts.
Concentration:

0.1 μM, 1 μM, 10 μM, 100 μM
Incubation Time:

24 h
Result:

Showed stimulation of the expression of genes involved in keratinocyte differentiation (KRT1, KRT10, FLG, IVL, LOR, TGM1) and antioxidative pathways (CAT, SOD1, SOD2).

Chemical Information

CAS. Nr. 39932-44-0
Appearance Solid
Molecular Weight 400.64
Formel C₂₇H₄₄O₂
Color White to off-white
SMILES

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)(O)C)([H])C(/C=C/C3=C(CC[C@@H](C3)O)C)=CCC1
Versand

Shipping with dry ice.
Speicherung

-80°C, protect from light, stored under nitrogen

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Slominski AT, et al., Metabolic activation of tachysterol3 to biologically active hydroxyderivatives that act on VDR, AhR, LXRs, and PPARγ receptors. FASEB J. 2022 Aug;36(8):e22451. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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25-Hydroxytachysterol3

MCE Bioactive Compound Library

Alle PPAR Isoform-spezifische Produkte anzeigen

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Chemical Information

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25-Hydroxytachysterol3 Related Classifications

HY-77278 Related Classifications