DSR-71167
DSR-71167 is an orally active mineralocorticoid receptor (MR) antagonist with an IC50 of 0.26 μM. DSR-71167 exhibits weak carbonic anhydrase (CA) inhibitory activity with an IC50 of 19 μM. DSR-71167 can dose-dependently increase urinary sodium excretion in rat models and has a very low risk of hyperkalemia in potassium-loading rat models. DSR-71167 lowers systolic blood pressure in hypertensive rat models. DSR-71167 can be used for research on hypertension and heart failure.
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- CAS. Nr.: 1355687-91-0
- Formel: C23H23ClF3N3O4S
- Molecular Weight:529.96
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Chemical Information
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CAS. Nr. 1355687-91-0
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Molecular Weight 529.96
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Formel C23H23ClF3N3O4S
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SMILES
O=C(C1=CC=C(C2=CC=CC=C2F)C(CNCC(F)F)=C1)NC3=CC=C(S(=O)(N)=O)C(OC)=C3.Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
DSR-71167 Related Classifications
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