1355687-91-0
Chemical Structure
DSR-71167
- CAS 番号: 1355687-91-0
- Formula:C23H23ClF3N3O4S
- Molecular Weight:529.96
IUPAC Name: 2-(((2,2-difluoroethyl)amino)methyl)-2'-fluoro-N-(3-methoxy-4-sulfamoylphenyl)-[1,1'-biphenyl]-4-carboxamide hydrochloride
InChIKey: ITRGCTKYRVBGJA-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C2=CC=CC=C2F)C(CNCC(F)F)=C1)NC3=CC=C(S(=O)(N)=O)C(OC)=C3.Cl
Biological Activity: DSR-71167 is an orally active mineralocorticoid receptor (MR) antagonist with an IC50 of 0.26 μM. DSR-71167 exhibits weak carbonic anhydrase (CA) inhibitory activity with an IC50 of 19 μM. DSR-71167 can dose-dependently increase urinary sodium excretion in rat models and has a very low risk of hyperkalemia in potassium-loading rat models. DSR-71167 lowers systolic blood pressure in hypertensive rat models. DSR-71167 can be used for research on hypertension and heart failure[1].
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DSR-71167 | DSR-71167 is an orally active mineralocorticoid receptor (MR) antagonist with an IC50 of 0.26 μM. DSR-71167 exhibits weak carbonic anhydrase (CA) inhibitory activity with an IC50 of 19 μM. DSR-71167 can dose-dependently increase urinary sodium excretion in rat models and has a very low risk of hyperkalemia in potassium-loading rat models. DSR-71167 lowers systolic blood pressure in hypertensive rat models. DSR-71167 can be used for research on hypertension and heart failure. | |||||||||||||||||||||
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Keywords
