PLK4 - polo like kinase 4 Gene

Also Known as SAK; STK18; MCCRP2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10733

About PLK4

Cytogenetic location: 4q28.1 Genomic coordinates (GRCh38): 4:127,880,893-127,899,224 (from NCBI)

This gene has 11 transcripts (splice variants), 210 orthologues, 4 paralogues and is associated with 5 phenotypes. Biased expression in testis (RPKM 12.2), bone marrow (RPKM 8.2) and 12 other tissues.

Summary

This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

PLK4 Products (6)

mRNA	Protein	Name
NM_001190799.2	NP_001177728.1	serine/threonine-protein kinase PLK4 isoform 2
NM_014264.5	NP_055079.3	serine/threonine-protein kinase PLK4 isoform 1
XM_017007662.2	XP_016863151.1	serine/threonine-protein kinase PLK4 isoform X1
XM_017007663.3	XP_016863152.1	serine/threonine-protein kinase PLK4 isoform X2
XM_005262701.4	XP_005262758.1	serine/threonine-protein kinase PLK4 isoform X3
NM_001190801.2	NP_001177730.1	serine/threonine-protein kinase PLK4 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	21725316	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in centriole replication	IDA IDA: Inferred from direct assay	21059844	GOA
involved in centriole replication	IMP IMP: Inferred from mutant phenotype	21725316	GOA
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	30804208	GOA
acts upstream of or within positive regulation of centriole replication	IDA IDA: Inferred from direct assay	22349705	GOA
involved in positive regulation of centriole replication	IDA IDA: Inferred from direct assay	27796307	GOA
involved in positive regulation of centriole replication	IMP IMP: Inferred from mutant phenotype	16244668	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	27796307	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in centriole	IDA IDA: Inferred from direct assay	16244668	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
located in procentriole	IDA IDA: Inferred from direct assay	24997597	GOA
part of procentriole replication complex	IPI IPI: Inferred from physical interaction	24997597	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLK4 Protein Structure

Pkinase

POLO_box

0
200
400
600
800
970 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase PLK4	Snk akin kinase serine/threonine-protein kinase 18 serine/threonine-protein kinase Sak

PLK4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	PLK4	O00444	OSBPL3	Homo sapiens	Q9H4L5	Validated Y2H	32296183
Intra	PLK4	O00444	OSBPL3	Homo sapiens	Q9H4L5	Y2H Prey Pooling	32296183
Intra	PLK4	O00444	OSBPL3	Homo sapiens	Q9H4L5	Y2H Array	32296183
Intra	PLK4	O00444	GAS8	Homo sapiens	O95995	Validated Y2H	32296183
Intra	PLK4	O00444	ECT2	Homo sapiens	Q9H8V3	Anti Bait CoIP	20348415
Intra	PLK4	O00444	ECT2	Homo sapiens	Q9H8V3	Anti Tag CoIP	20348415
Intra	PLK4	O00444	ECT2	Homo sapiens	Q9H8V3	Protein Kinase Assay	20348415
Intra	PLK4	O00444	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	PLK4	O00444	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	PLK4	O00444	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	PLK4	O00444	DNAJB13	Homo sapiens	P59910	Validated Y2H	32296183
Intra	PLK4	O00444	CEP152	Homo sapiens	O94986-3	FPS	24997597
Intra	PLK4	O00444	CEP152	Homo sapiens	O94986-3	GMS	24997597
Intra	PLK4	O00444	CEP152	Homo sapiens	O94986-3	Anti Tag CoIP	24997597
Intra	PLK4	O00444	CEP152	Homo sapiens	O94986-3	Anti Tag CoIP	21059844
Intra	PLK4	O00444	CEP152	Homo sapiens	O94986-3	Pull Down	24997597
Intra	PLK4	O00444	CEP152	Homo sapiens	O94986-3	Pull Down	20852615
Intra	PLK4	O00444	CEP152	Homo sapiens	O94986-3	Pull Down	21059844
Intra	PLK4	O00444	CEP152	Homo sapiens	O94986-3	X-Ray Diffraction	24997597
Intra	PLK4	O00444	CEP192	Homo sapiens	Q8TEP8-3	Anti Tag CoIP	24997597
Intra	PLK4	O00444	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	PLK4	O00444	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	32296183
Intra	PLK4	O00444	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	PLK4	O00444	CEP192	Homo sapiens	Q8TEP8	Pull Down	26188084
Intra	PLK4	O00444	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	33961781
Intra	PLK4	O00444	CEP152	Homo sapiens	O94986	Anti Bait CoIP	24997597
Intra	PLK4	O00444	CEP152	Homo sapiens	O94986	Anti Tag CoIP	26496610
Intra	PLK4	O00444	CEP152	Homo sapiens	O94986	Pull Down	26188084
Intra	PLK4	O00444	CEP152	Homo sapiens	O94986	Anti Bait CoIP	21059844
Intra	PLK4	O00444	CEP152	Homo sapiens	O94986	Anti Tag CoIP	26188084
Intra	PLK4	O00444	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	PLK4	O00444	P4HB	Homo sapiens	P07237	Validated Y2H	32814053
Intra	PLK4	O00444	P4HB	Homo sapiens	P07237	Y2H Pooling	32814053
Intra	PLK4	O00444	P4HB	Homo sapiens	P07237	Y2H Array	32814053
Intra	PLK4	O00444	SPAG5	Homo sapiens	Q96R06	Y2H Array	32296183
Intra	PLK4	O00444	SPAG5	Homo sapiens	Q96R06	Y2H Prey Pooling	32296183
Intra	PLK4	O00444	SPAG5	Homo sapiens	Q96R06	Validated Y2H	32296183
Intra	PLK4	O00444	SFN	Homo sapiens	P31947	Pull Down	16189514
Intra	PLK4	O00444	ARR3	Homo sapiens	P36575	Validated Y2H	25416956
Intra	PLK4	O00444	ELOA	Homo sapiens	Q14241	Y2H Prey Pooling	25416956
Intra	PLK4	O00444	ELOA	Homo sapiens	Q14241	Validated Y2H	25416956
Intra	PLK4	O00444	ELOA	Homo sapiens	Q14241	Validated Y2H	32296183
Intra	PLK4	O00444	ELOA	Homo sapiens	Q14241	Y2H Array	25416956
Intra	PLK4	O00444	PLK4	Homo sapiens	O00444	Y2H Pooling	16189514
Intra	PLK4	O00444	PLK4	Homo sapiens	O00444	Anti Tag CoIP	24997597
Intra	PLK4	O00444	STIL	Homo sapiens	Q15468	ITC	26188084
Intra	PLK4	O00444	STIL	Homo sapiens	Q15468	Anti Tag CoIP	26188084
Intra	PLK4	O00444	STIL	Homo sapiens	Q15468	Pull Down	26188084
Intra	PLK4	O00444	STIL	Homo sapiens	Q15468	IF	26188084
Intra	PLK4	O00444	STIL	Homo sapiens	Q15468	Protein Kinase Assay	26188084
Intra	PLK4	O00444	TENT5B	Homo sapiens	Q96A09	Validated Y2H	32296183
Intra	PLK4	O00444	AIRIM	Homo sapiens	Q9NX04	Y2H Array	25416956
Intra	PLK4	O00444	ZBTB39	Homo sapiens	O15060	Y2H Array	32296183
Intra	PLK4	O00444	ZBTB39	Homo sapiens	O15060	Y2H Prey Pooling	32296183
Intra	PLK4	O00444	ZBTB39	Homo sapiens	O15060	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

PLK4 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P89782	SAK/STK18/PLK4 Antibody (YA9126)	WB, IP, ELISA	human

Related Diseases

Diseases	Alias
Microcephaly And Chorioretinopathy, Autosomal Recessive, 2	MCCRP2 Microcephaly And Chorioretinopathy, Autosomal Recessive, Type 2
Microcephaly And Chorioretinopathy 2
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome
Mosaic Variegated Aneuploidy Syndrome	Warburton-Anyane-Yeboa Syndrome Mva Syndrome Mosaic Variegated Aneuplody Microcephaly Syndrome Warburton Anyane Yeboa Syndrome
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Seckel Syndrome	Microcephalic Primordial Dwarfism Bird-Headed Dwarfism Harper'S Syndrome Virchow-Seckel Dwarfism Nanocephalic Dwarfism Sckl Seckel-Type Dwarfism
Isolated Growth Hormone Deficiency, Type Ia	Ighd Ia Isolated Growth Hormone Deficiency Type Ia Primordial Dwarfism Sexual Ateleiotic Dwarfism Pituitary Dwarfism I IGHD1A Illig-Type Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, Type Ia Congenital Ighd Type Ia Congenital Isolated Gh Deficiency Type Ia Congenital Isolated Growth Hormone Deficiency Type Ia Pituitary Dwarfism 1 Growth Hormone Deficiency, Isolated, Autosomal Recessive Autosomal Recessive Isolated Growth Hormone Deficiency Isolated Growth Hormone Deficiency Type 1a Congenital Ighd Congenital Isolated Gh Deficiency Congenital Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated Autosomal Recessive Illig Type Growth Hormone Deficiency Non-Acquired Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, 1a Growth Hormone Deficiency Isolated Autosomal Recessive Dwarfism, Primordial Dwarfism
Autosomal Recessive Chorioretinopathy-Microcephaly Syndrome	Autosomal Recessive Chorioretinopathy-Microcephaly-Intellectual Disability Syndrome
Primary Microcephaly	True Microcephaly Microcephaly, Primary
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Spermatogenic Failure 10	SPGF10 Spermatogenic Failure With Defective Sperm Annulus Spermatogenic Failure, Type 10
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-12300	Ocifisertib	Inhibitor	99.78%	Phase 2
HY-12300B	Ocifisertib fumarate	Inhibitor	98.69%	Phase 2
HY-172737	RP-1664	Inhibitor	98.77%	Phase 1

Pre-clinical Phase

Bioactive Molecules (12)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-18682	Centrinone	Inhibitor	98.28%	Unkown
HY-100789	ON1231320	Inhibitor	99.90%	Unkown
HY-18683	Centrinone-B	Inhibitor	98.65%	Unkown
HY-128493	PLK4-IN-4	Inhibitor	99.89%	Unkown
HY-132135	(1E)-CFI-400437 dihydrochloride	Inhibitor	98.08%	Unkown
HY-149912	CZS-241	Inhibitor	/	Unkown
HY-12300A	Ocifisertib hydrochloride	Inhibitor	98.29%	Unkown
HY-176734	CZL-S092	Inhibitor	/	Unkown
HY-134775A	PLK4-IN-3	Inhibitor	/	Unkown
HY-179149	PLK4-IN-6	Inhibitor	/	Unkown
HY-115589	YLT-11	Inhibitor	/	Unkown
HY-180111	PLK4-IN-7	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PLK4	VGNC	VGNC:64246
Canis familiaris	PLK4	VGNC	VGNC:44698
Bos taurus	PLK4	VGNC	VGNC:33036
Macaca mulatta	PLK4	VGNC	VGNC:76019
Mus musculus	PLK4	MGD	MGI:101783
Rattus norvegicus	PLK4	RGD	RGD:1305390
Others	PLK4	NCBI