2. Cell Cycle/DNA Damage
  3. Polo-like Kinase (PLK)
  4. PLK4-IN-7

PLK4-IN-7 is a selective and orally active PLK4 inhibitor with an IC50 value of 7.9 nM. PLK4-IN-7 exhibits potent antitumor activity and favorable metabolic stability. PLK4-IN-7 can be used for the research of tumors such as neuroblastoma.

For research use only. We do not sell to patients.

PLK4-IN-7

PLK4-IN-7 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

PLK4-IN-7 Related Antibodies

Top Publications Citing Use of Products

View All Polo-like Kinase (PLK) Isoform Specific Products:

View All Isoforms
PLK1 PLK2 PLK3 PLK4

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PLK4-IN-7 is a selective and orally active PLK4 inhibitor with an IC50 value of 7.9 nM. PLK4-IN-7 exhibits potent antitumor activity and favorable metabolic stability. PLK4-IN-7 can be used for the research of tumors such as neuroblastoma[1].

IC50 & Target[1]

PLK4

7.9 nM (IC50)

In Vitro

PLK4-IN-7 (Compound 25) (5 days) can inhibit the viability of CHP-134 neuroblastoma cells, with an EC50 value of 88 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PLK4-IN-7 Related Antibodies
Parmacokinetics
Species Dose Route AUC0-24 Cmax Tmax
Mice[1] 30 mg/kg p.o. 28 μM·h 5.1 μM 0.5 h
Mice[1] 100 mg/kg p.o. 80 μM·h 11 μM 10 h
In Vivo

PLK4-IN-7 (30-100 mg/kg, p.o., twice daily for 16 days) has significant tumor growth inhibition in a CHP-134 neuroblastoma xenograft mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CHP-134 neuroblastoma tumor-bearing mouse xenograft model[1]
Dosage: 30 mg/kg, 100 mg/kg
Administration: p.o., twice daily for 16 days
Result: Was well-tolerated with no significant body weight loss observed during the treatment period, and the final tumor growth inhibition rates were 115% (30 mg/kg group) and 117% (100 mg/kg group), respectively.
Molecular Weight

503.40

Formula

C20H19F6N7O2
SMILES

O=C(NC1=CNN=C1C2=CC3=C(C=N2)C=NN3CC(F)(F)F)N4C5(C[C@@](C(F)(F)F)(CC4)O)CC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

PLK4-IN-7 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PLK4-IN-7Polo-like Kinase (PLK)oral activeneuroblastomaPLK4 inhibitorCHP-134 cellsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PLK4-IN-7
Cat. No.:
HY-180111
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.